Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1302615..1303410 Replicon chromosome
Accession NZ_CP031349
Organism Escherichia coli O145 strain RM9467-C1

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag DXE51_RS06575 Protein ID WP_000854914.1
Coordinates 1303036..1303410 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag DXE51_RS06570 Protein ID WP_001280953.1
Coordinates 1302615..1302989 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE51_RS06540 1297970..1298875 + 906 WP_000203541.1 chemotaxis protein -
DXE51_RS06545 1298872..1299942 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
DXE51_RS06550 1300282..1301100 + 819 WP_001234682.1 DUF945 domain-containing protein -
DXE51_RS06555 1301191..1301676 + 486 WP_000214398.1 antirestriction protein -
DXE51_RS06560 1301692..1302168 + 477 WP_001186738.1 RadC family protein -
DXE51_RS06565 1302231..1302452 + 222 WP_000692323.1 DUF987 domain-containing protein -
DXE51_RS06570 1302615..1302989 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DXE51_RS06575 1303036..1303410 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
DXE51_RS06580 1303407..1303898 + 492 WP_000976857.1 hypothetical protein -
DXE51_RS06585 1303910..1304107 + 198 WP_000839282.1 DUF957 domain-containing protein -
DXE51_RS06590 1304192..1305034 + 843 WP_001280481.1 DUF4942 domain-containing protein -
DXE51_RS06600 1305505..1306443 + 939 WP_000351301.1 glyoxylate/hydroxypyruvate reductase GhrA -
DXE51_RS06605 1306498..1307235 + 738 WP_000283664.1 zinc-binding phosphatase -
DXE51_RS06610 1307259..1307813 + 555 WP_001001917.1 molecular chaperone YcdY -
DXE51_RS06615 1307915..1308406 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1301692..1313343 11651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T109052 WP_000854914.1 NZ_CP031349:1303036-1303410 [Escherichia coli O145]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T109052 NZ_CP031349:1303036-1303410 [Escherichia coli O145]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT109052 WP_001280953.1 NZ_CP031349:1302615-1302989 [Escherichia coli O145]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT109052 NZ_CP031349:1302615-1302989 [Escherichia coli O145]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References