Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1302553..1303348 Replicon chromosome
Accession NZ_CP031345
Organism Escherichia coli O145 strain RM12367-C1

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag DXE53_RS06575 Protein ID WP_000854914.1
Coordinates 1302974..1303348 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag DXE53_RS06570 Protein ID WP_001280953.1
Coordinates 1302553..1302927 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE53_RS06540 1297908..1298813 + 906 WP_000203541.1 chemotaxis protein -
DXE53_RS06545 1298810..1299880 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
DXE53_RS06550 1300220..1301038 + 819 WP_001234682.1 DUF945 domain-containing protein -
DXE53_RS06555 1301129..1301614 + 486 WP_000214398.1 antirestriction protein -
DXE53_RS06560 1301630..1302106 + 477 WP_001186738.1 RadC family protein -
DXE53_RS06565 1302169..1302390 + 222 WP_000692323.1 DUF987 domain-containing protein -
DXE53_RS06570 1302553..1302927 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DXE53_RS06575 1302974..1303348 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
DXE53_RS06580 1303345..1303836 + 492 WP_000976857.1 hypothetical protein -
DXE53_RS06585 1303848..1304045 + 198 WP_000839282.1 DUF957 domain-containing protein -
DXE53_RS06590 1304130..1304972 + 843 WP_001280481.1 DUF4942 domain-containing protein -
DXE53_RS06600 1305443..1306381 + 939 WP_000351301.1 glyoxylate/hydroxypyruvate reductase GhrA -
DXE53_RS06605 1306436..1307173 + 738 WP_000283664.1 zinc-binding phosphatase -
DXE53_RS06610 1307197..1307751 + 555 WP_001001917.1 molecular chaperone YcdY -
DXE53_RS06615 1307853..1308344 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T108994 WP_000854914.1 NZ_CP031345:1302974-1303348 [Escherichia coli O145]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T108994 NZ_CP031345:1302974-1303348 [Escherichia coli O145]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT108994 WP_001280953.1 NZ_CP031345:1302553-1302927 [Escherichia coli O145]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT108994 NZ_CP031345:1302553-1302927 [Escherichia coli O145]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References