Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1635236..1635905 Replicon chromosome
Accession NZ_CP031249
Organism Haemophilus influenzae strain M15895

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag DV378_RS08220 Protein ID WP_015701504.1
Coordinates 1635236..1635619 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag DV378_RS08225 Protein ID WP_005651224.1
Coordinates 1635603..1635905 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV378_RS08185 1631996..1632319 + 324 WP_015701510.1 DUF2190 family protein -
DV378_RS08190 1632300..1632611 + 312 WP_015701509.1 hypothetical protein -
DV378_RS08195 1632614..1633144 + 531 WP_015701508.1 phage tail protein -
DV378_RS08200 1633153..1633563 + 411 WP_112072217.1 phage tail protein -
DV378_RS08205 1633566..1634216 + 651 WP_114934845.1 hypothetical protein -
DV378_RS08210 1634491..1634898 + 408 WP_038440705.1 hypothetical protein -
DV378_RS08215 1634943..1635167 + 225 WP_114934846.1 DUF4035 domain-containing protein -
DV378_RS08220 1635236..1635619 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV378_RS08225 1635603..1635905 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
DV378_RS08230 1635918..1636157 + 240 WP_114934847.1 hypothetical protein -
DV378_RS08235 1636209..1639580 + 3372 WP_114934848.1 phage tail tape measure protein -
DV378_RS08240 1639589..1639921 + 333 WP_038440713.1 phage tail protein -
DV378_RS09725 1640013..1640171 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1563062..1658697 95635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T108726 WP_015701504.1 NZ_CP031249:1635236-1635619 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T108726 NZ_CP031249:1635236-1635619 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT108726 WP_005651224.1 NZ_CP031249:1635603-1635905 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT108726 NZ_CP031249:1635603-1635905 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAGGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References