Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 375609..376855 Replicon chromosome
Accession NZ_CP031248
Organism Streptococcus pneumoniae strain M26365

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DV130_RS01960 Protein ID WP_114865136.1
Coordinates 375609..376379 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag DV130_RS01965 Protein ID WP_114865137.1
Coordinates 376379..376855 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV130_RS01945 370764..373043 + 2280 WP_050198960.1 ATP-binding protein -
DV130_RS01950 373027..374268 - 1242 WP_001865081.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
DV130_RS01955 374359..375255 + 897 WP_000384882.1 tyrosine-type recombinase/integrase -
DV130_RS01960 375609..376379 - 771 WP_114865136.1 zeta toxin family protein Toxin
DV130_RS01965 376379..376855 - 477 WP_114865137.1 helix-turn-helix domain-containing protein Antitoxin
DV130_RS01970 376925..377197 - 273 WP_000495448.1 hypothetical protein -
DV130_RS01975 377235..377618 - 384 WP_114865138.1 chemotaxis protein -
DV130_RS01980 377615..377848 - 234 WP_000152423.1 hypothetical protein -
DV130_RS01985 377899..378984 - 1086 Protein_388 toprim domain-containing protein -
DV130_RS01990 378994..379635 - 642 WP_114865139.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 355522..384834 29312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29461.45 Da        Isoelectric Point: 7.9259

>T108718 WP_114865136.1 NZ_CP031248:c376379-375609 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHTHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYILNPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

>T108718 NZ_CP031248:c376379-375609 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATACACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAGCTGTCCTATCTGAGCACTCTTATCCGATACGAAGAA
CTGTACATTCTCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18257.64 Da        Isoelectric Point: 4.4188

>AT108718 WP_114865137.1 NZ_CP031248:c376855-376379 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERVLEISEKRMVA

Download         Length: 477 bp

>AT108718 NZ_CP031248:c376855-376379 [Streptococcus pneumoniae]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTGTGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References