Detailed information of TA system TA108680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1653204..1653808
• Replicon: chromosome
• Accession: NZ_CP031237
• Organism: Haemophilus influenzae strain M12125

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DV365_RS08120
• Protein ID: WP_005694595.1
• Coordinates: 1653204..1653512 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: DV365_RS08125
• Protein ID: WP_005661259.1
• Coordinates: 1653512..1653808 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV365_RS08105	1648309..1649607	-	1299	WP_114890663.1	trigger factor	-
DV365_RS08115	1649971..1653147	+	3177	WP_205334680.1	TonB-dependent receptor	-
DV365_RS08120	1653204..1653512	-	309	WP_005694595.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DV365_RS08125	1653512..1653808	-	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DV365_RS08130	1653927..1654052	-	126	WP_005692348.1	hypothetical protein	-
DV365_RS08135	1654036..1655895	-	1860	WP_005694594.1	selenocysteine-specific translation elongation factor	-
DV365_RS08140	1655892..1657277	-	1386	WP_005694593.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11907.69 Da
• Isoelectric Point: 7.3189

>T108680 WP_005694595.1 NZ_CP031237:c1653512-1653204 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNIHSQTALK

Nucleotide

• Length: 309 bp

>T108680 NZ_CP031237:c1653512-1653204 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATATACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT108680 WP_005661259.1 NZ_CP031237:c1653808-1653512 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT108680 NZ_CP031237:c1653808-1653512 [Haemophilus influenzae]
ATGGCACTTACTAATTCCTCTATCAGTTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2