Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1370327..1370958 Replicon chromosome
Accession NZ_CP031237
Organism Haemophilus influenzae strain M12125

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag DV365_RS06705 Protein ID WP_005651560.1
Coordinates 1370560..1370958 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag DV365_RS06700 Protein ID WP_005648011.1
Coordinates 1370327..1370560 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV365_RS06675 1365806..1367008 - 1203 WP_114890555.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
DV365_RS06680 1367172..1367837 + 666 WP_013527272.1 DNA repair protein RadC -
DV365_RS06685 1368051..1368287 + 237 WP_005542826.1 50S ribosomal protein L28 -
DV365_RS06690 1368299..1368469 + 171 WP_005613503.1 50S ribosomal protein L33 -
DV365_RS06695 1368816..1370180 + 1365 WP_114890556.1 diaminobutyrate--2-oxoglutarate transaminase -
DV365_RS06700 1370327..1370560 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
DV365_RS06705 1370560..1370958 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
DV365_RS06710 1370978..1372513 + 1536 WP_114890557.1 L-2,4-diaminobutyrate decarboxylase -
DV365_RS06715 1372745..1373560 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
DV365_RS06720 1373634..1374656 - 1023 WP_005655937.1 outer membrane-stress sensor serine endopeptidase DegS -
DV365_RS06725 1374657..1375775 - 1119 WP_112071379.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T108679 WP_005651560.1 NZ_CP031237:1370560-1370958 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T108679 NZ_CP031237:1370560-1370958 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT108679 WP_005648011.1 NZ_CP031237:1370327-1370560 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT108679 NZ_CP031237:1370327-1370560 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References