Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 8062651..8063315 Replicon chromosome
Accession NZ_CP031142
Organism Saccharopolyspora pogona strain NRRL30141

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DL519_RS38185 Protein ID WP_168584913.1
Coordinates 8062920..8063315 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DL519_RS38180 Protein ID WP_190824465.1
Coordinates 8062651..8062923 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DL519_RS38165 8058448..8059602 + 1155 WP_190822092.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
DL519_RS38170 8059799..8060635 + 837 WP_190822094.1 GNAT family N-acetyltransferase -
DL519_RS38175 8060806..8062593 + 1788 WP_190822096.1 penicillin-binding protein -
DL519_RS38180 8062651..8062923 + 273 WP_190824465.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DL519_RS38185 8062920..8063315 + 396 WP_168584913.1 type II toxin-antitoxin system VapC family toxin Toxin
DL519_RS38190 8063566..8064399 + 834 WP_190813279.1 transposase -
DL519_RS38195 8064599..8065456 + 858 WP_190822098.1 type I methionyl aminopeptidase -
DL519_RS38200 8065898..8067418 + 1521 WP_190822100.1 cobyric acid synthase -
DL519_RS38205 8067517..8067765 + 249 WP_190822102.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14090.13 Da        Isoelectric Point: 5.1702

>T108538 WP_168584913.1 NZ_CP031142:8062920-8063315 [Saccharopolyspora pogona]
MIYFDSSALIKLIAPEPESKALSQWIRERWEHPRVTSALSKVDVLRTFREVGPAAEDLASIIVSKIDQLPVKQDVLDVAT
ELRGNVGPVDAIHLASACKIKNGLHAYVSYDPALLAAAEEAGLTTASPGAN

Download         Length: 396 bp

>T108538 NZ_CP031142:8062920-8063315 [Saccharopolyspora pogona]
TTGATCTACTTCGATTCCTCCGCGCTGATCAAGTTGATCGCCCCCGAGCCGGAGAGCAAAGCACTTAGCCAATGGATCCG
CGAGCGCTGGGAACACCCCCGCGTGACCAGCGCGTTGTCGAAGGTCGACGTGCTGCGCACCTTCCGTGAGGTAGGGCCGG
CCGCCGAAGACCTGGCGTCGATCATCGTGTCGAAGATCGACCAGCTGCCGGTGAAGCAGGACGTGCTCGACGTGGCCACC
GAGCTGCGTGGCAACGTCGGCCCGGTGGACGCCATCCACCTGGCCTCCGCGTGCAAGATCAAGAACGGTCTGCACGCCTA
CGTCTCCTACGACCCGGCGCTACTGGCTGCGGCGGAAGAAGCGGGGCTGACCACGGCCTCACCAGGCGCGAACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10008.36 Da        Isoelectric Point: 6.3673

>AT108538 WP_190824465.1 NZ_CP031142:8062651-8062923 [Saccharopolyspora pogona]
MERIGVRELRQNASRYLKRVAAGESILVTDRGRTVAVLSPPTRDQTLYDELVAAGELVPGEGGELPEPLPAAPTPNVSDR
LLRRREQERF

Download         Length: 273 bp

>AT108538 NZ_CP031142:8062651-8062923 [Saccharopolyspora pogona]
ATGGAGCGGATCGGCGTTCGTGAGCTGCGGCAGAACGCCAGTCGATACCTGAAGCGGGTCGCCGCCGGCGAATCGATCCT
CGTGACCGATCGGGGGCGCACCGTCGCGGTGCTAAGTCCGCCCACGCGTGACCAAACCCTGTACGACGAACTCGTCGCCG
CCGGAGAGCTCGTGCCCGGTGAAGGCGGCGAGCTCCCCGAACCGTTGCCAGCAGCGCCGACCCCGAACGTCTCCGACCGG
CTGCTGCGCAGGCGTGAACAGGAGCGGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References