Detailed information of TA system TA108537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 7274002..7274525
• Replicon: chromosome
• Accession: NZ_CP031142
• Organism: Saccharopolyspora pogona strain NRRL30141

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DL519_RS34200
• Protein ID: WP_190820962.1
• Coordinates: 7274002..7274262 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DL519_RS34205
• Protein ID: WP_190824392.1
• Coordinates: 7274259..7274525 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DL519_RS34180	7269969..7271435	+	1467	WP_190820956.1	hypothetical protein	-
DL519_RS34185	7271533..7272207	+	675	WP_190824391.1	phosphoribosylglycinamide formyltransferase	-
DL519_RS34190	7272204..7273769	+	1566	WP_190820958.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
DL519_RS34195	7273773..7273994	-	222	WP_190820960.1	hypothetical protein	-
DL519_RS34200	7274002..7274262	-	261	WP_190820962.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DL519_RS34205	7274259..7274525	-	267	WP_190824392.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DL519_RS34210	7274814..7275527	+	714	WP_190820964.1	hypothetical protein	-
DL519_RS34215	7275533..7277200	+	1668	WP_190820966.1	DNA polymerase Y family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9572.08 Da
• Isoelectric Point: 9.5794

>T108537 WP_190820962.1 NZ_CP031142:c7274262-7274002 [Saccharopolyspora pogona]
VTYTIKITARAGRDLACLPEKVASACAEFIFGPLAENPHRLGKPLFGEFKGLHSARRSAYRVVYAIQDDTVVVEVVRIAH
RADVYR

Nucleotide

• Length: 261 bp

>T108537 NZ_CP031142:c7274262-7274002 [Saccharopolyspora pogona]
GTGACCTACACGATCAAGATCACCGCACGTGCAGGGCGCGACCTCGCATGCCTCCCGGAGAAGGTCGCATCGGCTTGCGC
CGAGTTCATCTTCGGGCCGCTGGCCGAGAACCCGCACCGGCTCGGCAAACCACTGTTCGGAGAGTTCAAGGGCCTGCACT
CGGCTCGACGGAGCGCGTACCGCGTGGTGTACGCGATTCAAGACGACACCGTGGTGGTCGAAGTCGTCCGGATCGCCCAT
CGAGCCGACGTCTACCGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9728.83 Da
• Isoelectric Point: 4.2794

>AT108537 WP_190824392.1 NZ_CP031142:c7274525-7274259 [Saccharopolyspora pogona]
MTTIPLGEARDRLSEVVAQVESTHDRVEITRHGRPAAVLISPDDLSSLEETLDLLTTPGEAEAIREGVADAAAERFVDTE
EIKRRYLQ

Nucleotide

• Length: 267 bp

>AT108537 NZ_CP031142:c7274525-7274259 [Saccharopolyspora pogona]
ATGACGACGATCCCATTAGGAGAAGCCCGCGACCGGCTGTCAGAGGTGGTCGCGCAGGTCGAGAGCACCCATGATCGAGT
TGAAATCACTCGGCATGGTCGACCCGCCGCGGTCCTCATCTCCCCCGACGACCTGTCGTCCCTAGAAGAGACCCTGGACC
TACTGACCACTCCCGGTGAAGCGGAGGCCATTCGGGAGGGCGTGGCAGACGCGGCAGCGGAGCGCTTCGTTGACACCGAA
GAAATCAAGAGGCGCTACCTGCAGTGA