Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 4563181..4563854 Replicon chromosome
Accession NZ_CP031142
Organism Saccharopolyspora pogona strain NRRL30141

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DL519_RS20820 Protein ID WP_190817275.1
Coordinates 4563181..4563582 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DL519_RS20825 Protein ID WP_190824111.1
Coordinates 4563582..4563854 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DL519_RS20805 4559000..4560241 + 1242 WP_190817269.1 thiolase family protein -
DL519_RS20810 4560238..4562403 + 2166 WP_190817271.1 enoyl-CoA hydratase/isomerase family protein -
DL519_RS20815 4562512..4563093 + 582 WP_190817273.1 Uma2 family endonuclease -
DL519_RS20820 4563181..4563582 - 402 WP_190817275.1 type II toxin-antitoxin system VapC family toxin Toxin
DL519_RS20825 4563582..4563854 - 273 WP_190824111.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DL519_RS20830 4563896..4565041 - 1146 WP_190817277.1 HAMP domain-containing histidine kinase -
DL519_RS20835 4565046..4565732 - 687 WP_190817279.1 response regulator transcription factor -
DL519_RS20840 4565894..4567834 - 1941 WP_190817281.1 1-deoxy-D-xylulose-5-phosphate synthase -
DL519_RS20845 4568152..4568412 + 261 WP_190817283.1 hypothetical protein -
DL519_RS20850 4568516..4568704 + 189 WP_190817285.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14543.69 Da        Isoelectric Point: 5.9753

>T108535 WP_190817275.1 NZ_CP031142:c4563582-4563181 [Saccharopolyspora pogona]
VIYLDSAALIKLVRRERESDALADWLEQQPNVPLVASALVEVEVPRALRRYEPNLLSAAPAVLKRIGVYDIDDVVRATAA
AYQDVLLRSLDAIHLATAHAIFGSHLTAFVTYDHRLHKAAEDVGLPVAQPGTV

Download         Length: 402 bp

>T108535 NZ_CP031142:c4563582-4563181 [Saccharopolyspora pogona]
GTGATCTACCTCGACAGCGCTGCGCTCATCAAGCTGGTGAGACGGGAACGAGAAAGCGACGCACTGGCGGATTGGTTGGA
GCAACAGCCGAATGTACCGCTGGTCGCATCTGCGCTCGTCGAGGTGGAGGTTCCGCGGGCACTACGACGGTACGAACCGA
ACTTGCTCAGCGCCGCCCCCGCCGTTCTGAAGCGGATCGGCGTCTACGACATTGACGACGTGGTACGAGCTACGGCCGCT
GCGTACCAAGATGTCCTGCTGCGTTCACTCGACGCGATTCACCTTGCGACGGCACATGCGATCTTCGGTTCGCACCTGAC
GGCATTCGTGACCTACGACCATCGTCTCCACAAGGCGGCTGAAGATGTTGGATTGCCAGTCGCACAACCAGGAACGGTTT
GA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9989.51 Da        Isoelectric Point: 6.2274

>AT108535 WP_190824111.1 NZ_CP031142:c4563854-4563582 [Saccharopolyspora pogona]
MSEVPVRMLNQETSSVLARVKHGEEIDITERGVIIARIIPAHPHPLGELIASGKFRPPTLEGSMPRPLGPVRTDVDAGAL
IRELRDEERY

Download         Length: 273 bp

>AT108535 NZ_CP031142:c4563854-4563582 [Saccharopolyspora pogona]
ATGAGTGAGGTGCCGGTCCGCATGCTGAACCAGGAGACGTCGAGCGTCCTGGCCAGAGTCAAGCACGGCGAAGAAATCGA
CATCACCGAGCGCGGTGTCATCATCGCCAGGATCATTCCTGCGCATCCCCACCCTCTCGGCGAGCTGATCGCTTCTGGGA
AGTTCCGCCCGCCGACTCTGGAGGGGTCGATGCCCCGGCCACTCGGCCCTGTTCGAACTGACGTGGACGCGGGCGCGCTC
ATCCGTGAGCTACGAGATGAGGAGCGCTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References