Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4548746..4549380 Replicon chromosome
Accession NZ_CP031142
Organism Saccharopolyspora pogona strain NRRL30141

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DL519_RS20750 Protein ID WP_190817251.1
Coordinates 4548746..4549147 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DL519_RS20755 Protein ID WP_168590247.1
Coordinates 4549144..4549380 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DL519_RS20710 4544077..4544619 + 543 WP_190817242.1 AAA family ATPase -
DL519_RS20715 4544623..4545399 - 777 WP_190824110.1 DUF4389 domain-containing protein -
DL519_RS20720 4545792..4546091 + 300 WP_190817244.1 hypothetical protein -
DL519_RS20725 4546143..4547222 + 1080 WP_190817245.1 winged helix DNA-binding domain-containing protein -
DL519_RS20730 4547268..4547684 + 417 WP_190817247.1 peptide-methionine (R)-S-oxide reductase MsrB -
DL519_RS20735 4547964..4548353 + 390 WP_190817249.1 hypothetical protein -
DL519_RS20740 4548363..4548488 - 126 Protein_4139 chlorite dismutase family protein -
DL519_RS20745 4548519..4548742 + 224 Protein_4140 peptide-methionine (R)-S-oxide reductase -
DL519_RS20750 4548746..4549147 - 402 WP_190817251.1 PIN domain-containing protein Toxin
DL519_RS20755 4549144..4549380 - 237 WP_168590247.1 antitoxin Antitoxin
DL519_RS20760 4549435..4550130 - 696 WP_190817253.1 chlorite dismutase family protein -
DL519_RS20765 4550135..4551571 - 1437 WP_190817256.1 protoporphyrinogen oxidase -
DL519_RS20770 4551571..4552662 - 1092 WP_190817258.1 uroporphyrinogen decarboxylase -
DL519_RS20775 4552915..4553493 + 579 WP_190817260.1 DUF3000 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14392.63 Da        Isoelectric Point: 6.3256

>T108534 WP_190817251.1 NZ_CP031142:c4549147-4548746 [Saccharopolyspora pogona]
MSEFVVDASTLVLATTVVSDGAREVRRRLLQSECHAPHLVDAEVGNVLRRQELGGQIEAEAATTALLAMKHLVDHRYPHV
GPLSQAAWELRGAVTFYDALYVALAAGLDVPLLTADARLSRAPKLPCKVELIV

Download         Length: 402 bp

>T108534 NZ_CP031142:c4549147-4548746 [Saccharopolyspora pogona]
TTGAGCGAATTCGTCGTTGACGCCTCGACCCTCGTGCTGGCAACCACAGTCGTGTCGGACGGGGCCCGTGAGGTGCGCCG
TCGGCTGCTGCAGAGCGAGTGCCACGCACCGCACCTTGTCGACGCAGAGGTCGGGAACGTGCTTAGAAGGCAGGAGTTGG
GCGGGCAGATCGAGGCGGAAGCCGCGACGACTGCGCTCCTCGCGATGAAGCACTTGGTCGACCACCGCTATCCCCATGTA
GGTCCGCTCAGCCAAGCCGCGTGGGAGTTGCGTGGTGCGGTCACGTTCTATGACGCGCTCTACGTGGCGCTCGCTGCTGG
CCTGGACGTGCCGCTGCTGACAGCCGACGCGAGGCTGTCCCGCGCTCCCAAGCTCCCGTGCAAGGTGGAATTGATCGTGT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8675.88 Da        Isoelectric Point: 8.6008

>AT108534 WP_168590247.1 NZ_CP031142:c4549380-4549144 [Saccharopolyspora pogona]
MATIQIRDIPEEAYETIRKRARSAGMSLQAYMRDEVVRMASRRTKEEALAAVEAALAHDRGTGVTVESILAAKDADRR

Download         Length: 237 bp

>AT108534 NZ_CP031142:c4549380-4549144 [Saccharopolyspora pogona]
ATGGCGACCATTCAGATCCGGGACATCCCGGAAGAGGCGTACGAGACGATCCGCAAACGAGCACGATCCGCTGGGATGTC
GCTGCAGGCCTACATGCGCGATGAAGTCGTGCGCATGGCGTCGCGCCGGACGAAGGAAGAAGCGCTCGCGGCGGTCGAGG
CGGCACTCGCTCACGATCGCGGCACCGGAGTGACCGTCGAGAGCATCCTCGCGGCAAAGGATGCTGATCGGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References