Detailed information of TA system TA108496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3387242..3387827
• Replicon: chromosome
• Accession: NZ_CP031123
• Organism: Providencia huaxiensis strain WCHPr000369

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CYG50_RS17255
• Protein ID: WP_102138200.1
• Coordinates: 3387242..3387559 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4C3P0
• Locus tag: CYG50_RS17260
• Protein ID: WP_004905876.1
• Coordinates: 3387540..3387827 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYG50_RS17225	3382947..3383198	-	252	WP_102138194.1	DUF1471 domain-containing protein	-
CYG50_RS17230	3383468..3383806	+	339	WP_102138195.1	GIY-YIG nuclease family protein	-
CYG50_RS17235	3383779..3384282	-	504	WP_102138196.1	N-acetyltransferase	-
CYG50_RS17240	3384276..3384800	-	525	WP_102138197.1	SCP2 domain-containing protein	-
CYG50_RS17245	3385314..3386309	+	996	WP_102138198.1	U32 family peptidase	-
CYG50_RS17250	3386327..3387202	+	876	WP_102138199.1	U32 family peptidase	-
CYG50_RS17255	3387242..3387559	-	318	WP_102138200.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CYG50_RS17260	3387540..3387827	-	288	WP_004905876.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CYG50_RS17265	3387958..3389112	-	1155	WP_102138201.1	ABC transporter permease	-
CYG50_RS17270	3389112..3390257	-	1146	WP_102138202.1	ABC transporter permease	-
CYG50_RS17275	3390269..3391240	-	972	WP_102138203.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (14-105)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-75)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12221.96 Da
• Isoelectric Point: 9.7799

>T108496 WP_102138200.1 NZ_CP031123:c3387559-3387242 [Providencia huaxiensis]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGSRELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Nucleotide

• Length: 318 bp

>T108496 NZ_CP031123:c3387559-3387242 [Providencia huaxiensis]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGAAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGATCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10763.44 Da
• Isoelectric Point: 5.8809

>AT108496 WP_004905876.1 NZ_CP031123:c3387827-3387540 [Providencia huaxiensis]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Nucleotide

• Length: 288 bp

>AT108496 NZ_CP031123:c3387827-3387540 [Providencia huaxiensis]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAGCAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TCAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A345M0A6