Detailed information of TA system TA108474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 150139..150515
• Replicon: plasmid pAMSC2
• Accession: NZ_CP031107
• Organism: Escherichia coli strain AMSCJX02

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: DUT84_RS26480
• Protein ID: WP_000969988.1
• Coordinates: 150139..150321 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: DUT84_RS26485
• Protein ID: WP_001324224.1
• Coordinates: 150318..150515 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DUT84_RS26465	148138..149172	-	1035	WP_001190233.1	3-deoxy-7-phosphoheptulonate synthase	-
DUT84_RS26475	149732..150040	-	309	WP_074417013.1	hypothetical protein	-
DUT84_RS26480	150139..150321	-	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DUT84_RS26485	150318..150515	-	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
DUT84_RS26490	151197..152471	+	1275	WP_000489608.1	HlyD family secretion protein	-
DUT84_RS26495	152446..154560	+	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
DUT84_RS26500	154730..155041	-	312	WP_001259758.1	colicin V	-
DUT84_RS28605	155019..155255	-	237	WP_001323890.1	colicin V immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat	1..203856	203856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T108474 WP_000969988.1 NZ_CP031107:c150321-150139 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T108474 NZ_CP031107:c150321-150139 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT108474 WP_001324224.1 NZ_CP031107:c150515-150318 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT108474 NZ_CP031107:c150515-150318 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A075MDK3