108348

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 112665..113270 Replicon chromosome
Accession NZ_CP031030
Organism Runella sp. SP2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DTQ70_RS00455 Protein ID WP_122928979.1
Coordinates 112665..112943 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DTQ70_RS00460 Protein ID WP_122928980.1
Coordinates 112956..113270 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTQ70_RS00440 108860..110401 + 1542 WP_122928976.1 hypothetical protein -
DTQ70_RS00445 110411..111166 + 756 WP_122928977.1 enoyl-CoA hydratase/isomerase family protein -
DTQ70_RS00450 111163..112425 - 1263 WP_122928978.1 replication-associated recombination protein A -
DTQ70_RS00455 112665..112943 + 279 WP_122928979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DTQ70_RS00460 112956..113270 + 315 WP_122928980.1 HigA family addiction module antidote protein Antitoxin
DTQ70_RS00465 113378..113896 + 519 WP_122928981.1 GNAT family N-acetyltransferase -
DTQ70_RS00470 113965..114546 - 582 WP_028521893.1 sigma-70 family RNA polymerase sigma factor -
DTQ70_RS00475 114640..116286 - 1647 WP_122928982.1 adenine deaminase -
DTQ70_RS00480 116448..116759 + 312 WP_028521891.1 hypothetical protein -
DTQ70_RS00485 116898..117554 + 657 WP_122928983.1 NAD(P)H-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10581.07 Da        Isoelectric Point: 6.4773

>T108348 WP_122928979.1 NZ_CP031030:112665-112943 [Runella sp. SP2]
MIQSIRHKGLLQYYTEGNGSKLPAQYLRKINRILDQLDAVSSVDDIQAMGLGIHKLTGDLADFWSIKVTPNYRIIFRFEG
GDIHDIDFLDYH

Download         Length: 279 bp

>T108348 NZ_CP031030:112665-112943 [Runella sp. SP2]
ATGATACAGTCCATTCGGCACAAAGGCTTGTTACAATACTATACCGAAGGCAATGGTTCAAAGCTACCCGCCCAATATTT
GCGAAAGATTAACCGTATATTAGACCAGTTAGACGCGGTTTCATCGGTTGATGATATTCAGGCAATGGGTTTAGGTATTC
ACAAACTTACAGGCGATTTGGCAGATTTTTGGTCTATCAAAGTTACCCCCAACTATCGGATTATCTTTCGATTTGAAGGG
GGCGATATTCACGACATAGATTTTTTAGATTATCACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11903.52 Da        Isoelectric Point: 7.4030

>AT108348 WP_122928980.1 NZ_CP031030:112956-113270 [Runella sp. SP2]
MLKRNLPPVHPGEILREDYINEHNLTITEVAEGLGIARANLSAIVNGRAGISPEMAVKLAEAFGNTPQFWGNLQKNYELW
HAERTVNRSKIRHFWEEWKSVQPT

Download         Length: 315 bp

>AT108348 NZ_CP031030:112956-113270 [Runella sp. SP2]
ATGTTAAAGCGCAACTTACCGCCAGTTCACCCAGGGGAAATATTACGGGAAGATTACATTAACGAACATAATTTGACCAT
TACGGAAGTAGCGGAAGGTTTGGGCATTGCCCGTGCTAATTTATCGGCCATCGTCAACGGACGAGCAGGGATAAGCCCCG
AAATGGCCGTAAAGTTGGCCGAGGCGTTTGGCAATACCCCACAATTTTGGGGAAATTTGCAGAAAAACTACGAACTTTGG
CACGCCGAACGCACGGTAAACCGCTCAAAAATTCGTCATTTTTGGGAAGAATGGAAGAGCGTACAGCCGACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References