Detailed information of TA system TA108035

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3956410..3956667
• Replicon: chromosome
• Accession: NZ_CP030783
• Organism: Escherichia albertii strain 2012EL-1823B

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: AYN53_RS20075
• Protein ID: WP_001135738.1
• Coordinates: 3956410..3956562 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3956619..3956667 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYN53_RS20050	3952514..3953173	+	660	WP_000747625.1	OmpA family lipoprotein	-
AYN53_RS20055	3953277..3954251	+	975	WP_059221283.1	glyoxylate/hydroxypyruvate reductase GhrB	-
AYN53_RS20060	3954304..3955014	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
AYN53_RS20065	3955437..3955727	+	291	WP_059221281.1	HTH-type transcriptional regulator	-
AYN53_RS20070	3956010..3956222	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
AYN53_RS20075	3956410..3956562	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3956619..3956667	+	49	-	-	Antitoxin
AYN53_RS20080	3956884..3958953	-	2070	WP_059221279.1	glycine--tRNA ligase subunit beta	-
AYN53_RS20085	3958963..3959874	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
AYN53_RS20090	3959970..3960269	-	300	WP_000979961.1	YsaB family lipoprotein	-
AYN53_RS20095	3960442..3961437	+	996	WP_059221277.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T108035 WP_001135738.1 NZ_CP030783:c3956562-3956410 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T108035 NZ_CP030783:c3956562-3956410 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT108035 NZ_CP030783:3956619-3956667 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin