Detailed information of TA system TA108010

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-timR/SymE(toxin)
• Location: 26328..26740
• Replicon: chromosome
• Accession: NZ_CP030783
• Organism: Escherichia albertii strain 2012EL-1823B

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: AYN53_RS00125
• Protein ID: WP_113649425.1
• Coordinates: 26328..26669 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	timR
Locus tag	-
Coordinates	26664..26740 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYN53_RS00105	21840..22289	+	450	WP_164473971.1	Rpn family recombination-promoting nuclease/putative transposase	-
AYN53_RS00110	22957..23685	+	729	Protein_20	hypothetical protein	-
AYN53_RS00115	23741..24787	-	1047	Protein_21	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
AYN53_RS00120	24787..26166	-	1380	WP_113649424.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
AYN53_RS00125	26328..26669	-	342	WP_113649425.1	endoribonuclease SymE	Toxin
-	26664..26740	+	77	NuclAT_10	-	Antitoxin
-	26664..26740	+	77	NuclAT_10	-	Antitoxin
-	26664..26740	+	77	NuclAT_10	-	Antitoxin
-	26664..26740	+	77	NuclAT_10	-	Antitoxin
-	26664..26740	+	77	NuclAT_9	-	Antitoxin
-	26664..26740	+	77	NuclAT_9	-	Antitoxin
-	26664..26740	+	77	NuclAT_9	-	Antitoxin
-	26664..26740	+	77	NuclAT_9	-	Antitoxin
AYN53_RS00130	26897..28246	-	1350	WP_113649426.1	restriction endonuclease subunit S	-
AYN53_RS00135	28243..29832	-	1590	WP_113649427.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12334.19 Da
• Isoelectric Point: 8.4951

>T108010 WP_113649425.1 NZ_CP030783:c26669-26328 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAIPLKGQWLEAAGFVTGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVRDFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T108010 NZ_CP030783:c26669-26328 [Escherichia albertii]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCCCCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGTCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAACTATCGGCGCGTAAACAAAAGCAGGTGCGGGATTTTATTGGGGTAATTGC
GGGTAAACAGAAAGTTGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT108010 NZ_CP030783:26664-26740 [Escherichia albertii]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin