Detailed information of TA system TA107973

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 16472..16726
• Replicon: plasmid unnamed2
• Accession: NZ_CP030780
• Organism: Escherichia albertii strain 05-3106

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: CYM74_RS23695
• Protein ID: WP_032186826.1
• Coordinates: 16472..16678 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	16670..16726 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYM74_RS23655	12504..12905	-	402	WP_001398199.1	type II toxin-antitoxin system toxin endoribonuclease PemK	-
CYM74_RS23660	12838..13095	-	258	WP_000557619.1	type II toxin-antitoxin system antitoxin PemI	-
CYM74_RS23665	13188..13841	-	654	WP_000616807.1	CPBP family intramembrane metalloprotease	-
CYM74_RS23675	14781..15638	-	858	WP_000130987.1	incFII family plasmid replication initiator RepA	-
CYM74_RS23680	15631..15705	-	75	WP_001365571.1	RepA leader peptide Tap	-
CYM74_RS23690	15928..16188	-	261	WP_000083817.1	replication regulatory protein RepA	-
CYM74_RS23695	16472..16678	-	207	WP_032186826.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	16670..16726	+	57	NuclAT_1	-	Antitoxin
-	16670..16726	+	57	NuclAT_1	-	Antitoxin
-	16670..16726	+	57	NuclAT_1	-	Antitoxin
-	16670..16726	+	57	NuclAT_1	-	Antitoxin
CYM74_RS23705	16970..17152	+	183	WP_001393357.1	hypothetical protein	-
CYM74_RS23710	17377..18108	-	732	WP_001071488.1	type-F conjugative transfer system pilin acetylase TraX	-
CYM74_RS23715	18105..18671	-	567	WP_000469207.1	DUF2726 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	sul1 / tet(A) / blaTEM-1B / dfrA15 / ant(3'')-Ia	-	1..80632	80632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7822.32 Da
• Isoelectric Point: 8.8807

>T107973 WP_032186826.1 NZ_CP030780:c16678-16472 [Escherichia albertii]
MKYLNTTDCSLFLAERSKFMTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 207 bp

>T107973 NZ_CP030780:c16678-16472 [Escherichia albertii]
ATGAAGTACTTGAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATACCCTTATTGG
GTTGCTCGCCGTGTGTGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT107973 NZ_CP030780:16670-16726 [Escherichia albertii]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin