Detailed information of TA system TA107685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2421160..2421692
• Replicon: chromosome
• Accession: NZ_CP030323
• Organism: Staphylococcus aureus strain AR_475

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CSC60_RS12325
• Protein ID: WP_001103942.1
• Coordinates: 2421160..2421480 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CSC60_RS12330
• Protein ID: WP_001058486.1
• Coordinates: 2421483..2421692 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC60_RS12290	2416311..2416652	-	342	WP_001190615.1	hypothetical protein	-
CSC60_RS12295	2417169..2417810	-	642	WP_001019764.1	hypothetical protein	-
CSC60_RS12300	2417807..2418091	-	285	WP_000998181.1	hypothetical protein	-
CSC60_RS12305	2418093..2418455	-	363	WP_001039168.1	hypothetical protein	-
CSC60_RS12315	2418741..2420210	-	1470	WP_000390454.1	virulence-associated E family protein	-
CSC60_RS12320	2420227..2421096	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CSC60_RS12325	2421160..2421480	-	321	WP_001103942.1	DUF1474 family protein	Toxin
CSC60_RS12330	2421483..2421692	-	210	WP_001058486.1	hypothetical protein	Antitoxin
CSC60_RS12335	2421685..2421831	-	147	WP_000784875.1	hypothetical protein	-
CSC60_RS12340	2421843..2422115	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CSC60_RS12345	2422108..2422371	-	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
CSC60_RS12350	2422564..2422896	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CSC60_RS12355	2422908..2423366	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CSC60_RS12360	2423383..2423814	+	432	WP_001228759.1	hypothetical protein	-
CSC60_RS12365	2423884..2424612	+	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
CSC60_RS12370	2424636..2425364	+	729	WP_000733774.1	staphylococcal enterotoxin type K	-
CSC60_RS12375	2425453..2426673	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk	2411360..2446627	35267

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T107685 WP_001103942.1 NZ_CP030323:c2421480-2421160 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T107685 NZ_CP030323:c2421480-2421160 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT107685 WP_001058486.1 NZ_CP030323:c2421692-2421483 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT107685 NZ_CP030323:c2421692-2421483 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4