Detailed information of TA system TA107577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4655800..4656316
• Replicon: chromosome
• Accession: NZ_CP030302
• Organism: Klebsiella pneumoniae strain 205880

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DRB04_RS22635
• Protein ID: WP_040216106.1
• Coordinates: 4655800..4656084 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: DRB04_RS22640
• Protein ID: WP_002886901.1
• Coordinates: 4656074..4656316 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRB04_RS22610 (DRB04_23135)	4651217..4651480	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
DRB04_RS22615	4651610..4651783	+	174	WP_032425422.1	hypothetical protein	-
DRB04_RS22620 (DRB04_23140)	4651786..4652529	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
DRB04_RS22625 (DRB04_23145)	4652886..4655024	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
DRB04_RS22630 (DRB04_23150)	4655332..4655796	+	465	WP_032418146.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
DRB04_RS22635 (DRB04_23155)	4655800..4656084	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DRB04_RS22640 (DRB04_23160)	4656074..4656316	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DRB04_RS22645 (DRB04_23165)	4656394..4658304	-	1911	WP_040216105.1	PRD domain-containing protein	-
DRB04_RS22650 (DRB04_23170)	4658327..4659481	-	1155	WP_040216103.1	lactonase family protein	-
DRB04_RS22655 (DRB04_23175)	4659548..4660288	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T107577 WP_040216106.1 NZ_CP030302:c4656084-4655800 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T107577 NZ_CP030302:c4656084-4655800 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT107577 WP_002886901.1 NZ_CP030302:c4656316-4656074 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT107577 NZ_CP030302:c4656316-4656074 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0