Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4932507..4933023 Replicon chromosome
Accession NZ_CP030292
Organism Klebsiella pneumoniae strain 721005

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag DRB00_RS24380 Protein ID WP_002886902.1
Coordinates 4932507..4932791 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DRB00_RS24385 Protein ID WP_002886901.1
Coordinates 4932781..4933023 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DRB00_RS24355 (DRB00_25085) 4927991..4928254 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
DRB00_RS24360 4928384..4928557 + 174 WP_002886906.1 hypothetical protein -
DRB00_RS24365 (DRB00_25090) 4928560..4929303 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
DRB00_RS24370 (DRB00_25095) 4929660..4931798 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
DRB00_RS24375 (DRB00_25100) 4932039..4932503 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DRB00_RS24380 (DRB00_25105) 4932507..4932791 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DRB00_RS24385 (DRB00_25110) 4932781..4933023 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DRB00_RS24390 (DRB00_25115) 4933101..4935011 - 1911 WP_004152270.1 PRD domain-containing protein -
DRB00_RS24395 (DRB00_25120) 4935034..4936188 - 1155 WP_002886900.1 lactonase family protein -
DRB00_RS24400 (DRB00_25125) 4936254..4936994 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T107502 WP_002886902.1 NZ_CP030292:c4932791-4932507 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T107502 NZ_CP030292:c4932791-4932507 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT107502 WP_002886901.1 NZ_CP030292:c4933023-4932781 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT107502 NZ_CP030292:c4933023-4932781 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References