Detailed information of TA system TA107331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 5142465..5143204
• Replicon: chromosome
• Accession: NZ_CP030174
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain 11219

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: DQB71_RS26130
• Protein ID: WP_021312536.1
• Coordinates: 5142465..5142950 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: L7SZ29
• Locus tag: DQB71_RS26135
• Protein ID: WP_003026799.1
• Coordinates: 5142938..5143204 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQB71_RS26105	5138095..5138385	+	291	WP_002921931.1	HTH-type transcriptional regulator	-
DQB71_RS26110	5138638..5138850	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
DQB71_RS26115	5138949..5140568	-	1620	WP_065890224.1	ATP-binding cassette domain-containing protein	-
DQB71_RS26120	5140873..5141022	-	150	WP_065890222.1	type I toxin-antitoxin system toxin HokA	-
DQB71_RS26125	5141094..5142140	+	1047	WP_112162883.1	IS481 family transposase	-
DQB71_RS26130	5142465..5142950	-	486	WP_021312536.1	GNAT family N-acetyltransferase	Toxin
DQB71_RS26135	5142938..5143204	-	267	WP_003026799.1	DUF1778 domain-containing protein	Antitoxin
DQB71_RS26140	5143337..5143765	-	429	WP_004901287.1	GFA family protein	-
DQB71_RS26150	5145631..5147700	-	2070	WP_065889575.1	glycine--tRNA ligase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5127403..5145335	17932
	-	inside	IScluster/Tn	-	-	5141094..5144691	3597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17608.39 Da
• Isoelectric Point: 10.3370

>T107331 WP_021312536.1 NZ_CP030174:c5142950-5142465 [Klebsiella pneumoniae subsp. pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T107331 NZ_CP030174:c5142950-5142465 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10147.59 Da
• Isoelectric Point: 4.5256

>AT107331 WP_003026799.1 NZ_CP030174:c5143204-5142938 [Klebsiella pneumoniae subsp. pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT107331 NZ_CP030174:c5143204-5142938 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q8YL66