Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 8433..8955 | Replicon | plasmid pJSMCR1_4 |
| Accession | NZ_CP030156 | ||
| Organism | Escherichia coli strain JSMCR1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | JSMCR1_RS25450 | Protein ID | WP_000638823.1 |
| Coordinates | 8433..8714 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | JSMCR1_RS25455 | Protein ID | WP_000121741.1 |
| Coordinates | 8704..8955 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSMCR1_RS25415 (JSMCR1_p563) | 4582..4902 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| JSMCR1_RS25420 (JSMCR1_p564) | 4973..5263 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| JSMCR1_RS25425 (JSMCR1_p565) | 5263..5847 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| JSMCR1_RS25430 (JSMCR1_p566) | 5868..6266 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| JSMCR1_RS25435 (JSMCR1_p567) | 6385..6822 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| JSMCR1_RS25440 (JSMCR1_p568) | 6828..8063 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| JSMCR1_RS25445 (JSMCR1_p569) | 8066..8365 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| JSMCR1_RS25450 (JSMCR1_p570) | 8433..8714 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JSMCR1_RS25455 (JSMCR1_p571) | 8704..8955 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| JSMCR1_RS25460 (JSMCR1_p572) | 9055..9690 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| JSMCR1_RS25465 (JSMCR1_p573) | 9763..10050 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| JSMCR1_RS25470 (JSMCR1_p574) | 10063..10317 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| JSMCR1_RS25475 (JSMCR1_p575) | 10319..10960 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| JSMCR1_RS25480 (JSMCR1_p576) | 10966..11961 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| JSMCR1_RS25485 (JSMCR1_p577) | 11965..12222 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| JSMCR1_RS25490 (JSMCR1_p578) | 12219..12521 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| JSMCR1_RS25495 (JSMCR1_p579) | 12502..12759 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| JSMCR1_RS25500 (JSMCR1_p580) | 12792..13238 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| JSMCR1_RS25505 (JSMCR1_p581) | 13249..13419 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| JSMCR1_RS25510 (JSMCR1_p582) | 13423..13866 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61828 | 61828 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T107252 WP_000638823.1 NZ_CP030156:c8714-8433 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T107252 NZ_CP030156:c8714-8433 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT107252 WP_000121741.1 NZ_CP030156:c8955-8704 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT107252 NZ_CP030156:c8955-8704 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|