Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4300354..4301189 Replicon chromosome
Accession NZ_CP030152
Organism Escherichia coli strain JSMCR1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A402UK40
Locus tag JSMCR1_RS20880 Protein ID WP_000854718.1
Coordinates 4300812..4301189 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A746C7X0
Locus tag JSMCR1_RS20875 Protein ID WP_001285485.1
Coordinates 4300354..4300722 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSMCR1_RS20835 (4296269) 4296269..4296946 + 678 WP_001097368.1 hypothetical protein -
JSMCR1_RS20840 (4296952) 4296952..4297185 + 234 WP_001278287.1 DUF905 family protein -
JSMCR1_RS20845 (4297275) 4297275..4298093 + 819 WP_256625251.1 DUF932 domain-containing protein -
JSMCR1_RS20850 (4298119) 4298119..4298259 - 141 WP_000997937.1 hypothetical protein -
JSMCR1_RS20855 (4298359) 4298359..4298838 + 480 WP_001696591.1 antirestriction protein -
JSMCR1_RS20860 (4298854) 4298854..4299330 + 477 WP_053289525.1 RadC family protein -
JSMCR1_RS20865 (4299417) 4299417..4299638 + 222 WP_000692295.1 DUF987 domain-containing protein -
JSMCR1_RS20870 (4299657) 4299657..4300304 + 648 WP_000094918.1 hypothetical protein -
JSMCR1_RS20875 (4300354) 4300354..4300722 + 369 WP_001285485.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSMCR1_RS20880 (4300812) 4300812..4301189 + 378 WP_000854718.1 TA system toxin CbtA family protein Toxin
JSMCR1_RS20885 (4301186) 4301186..4301674 + 489 WP_000761678.1 DUF5983 family protein -
JSMCR1_RS20890 (4301686) 4301686..4301883 + 198 WP_000839239.1 DUF957 domain-containing protein -
JSMCR1_RS20895 (4301968) 4301968..4302834 + 867 WP_001280433.1 DUF4942 domain-containing protein -
JSMCR1_RS20900 (4302906) 4302906..4303169 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
JSMCR1_RS20905 (4303166) 4303166..4303492 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JSMCR1_RS20910 (4304375) 4304375..4305913 + 1539 WP_001187173.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14185.12 Da        Isoelectric Point: 6.9576

>T107239 WP_000854718.1 NZ_CP030152:4300812-4301189 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T107239 NZ_CP030152:4300812-4301189 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACTCCATTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AACGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13727.30 Da        Isoelectric Point: 4.8166

>AT107239 WP_001285485.1 NZ_CP030152:4300354-4300722 [Escherichia coli]
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT

Download         Length: 369 bp

>AT107239 NZ_CP030152:4300354-4300722 [Escherichia coli]
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A402UK40

Antitoxin

Source ID Structure
AlphaFold DB A0A746C7X0

References