Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2749686..2750334 Replicon chromosome
Accession NZ_CP030093
Organism Mycobacterium tuberculosis strain RUS_B0

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag DPM14_RS13275 Protein ID WP_003899414.1
Coordinates 2749686..2750009 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag DPM14_RS13280 Protein ID WP_003899415.1
Coordinates 2750089..2750334 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPM14_RS13245 2745009..2746007 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
DPM14_RS13250 2746021..2746485 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
DPM14_RS13255 2746473..2746724 + 252 WP_003908028.1 hypothetical protein -
DPM14_RS13260 2746895..2748334 - 1440 WP_003901443.1 phage major capsid protein -
DPM14_RS13265 2748342..2748875 - 534 WP_003899412.1 HK97 family phage prohead protease -
DPM14_RS13270 2749028..2749519 - 492 WP_003900541.1 phage terminase small subunit P27 family -
DPM14_RS13275 2749686..2750009 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
DPM14_RS13280 2750089..2750334 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
DPM14_RS13285 2750331..2751758 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
DPM14_RS13290 2751760..2752152 - 393 WP_003899417.1 DUF2742 domain-containing protein -
DPM14_RS13295 2752149..2752409 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
DPM14_RS13300 2752426..2752788 - 363 WP_003900543.1 hypothetical protein -
DPM14_RS13305 2752791..2753918 - 1128 WP_003899420.1 site-specific integrase -
DPM14_RS13310 2754063..2754290 - 228 WP_003899421.1 hypothetical protein -
DPM14_RS13315 2754287..2754676 - 390 WP_003899422.1 hypothetical protein -
DPM14_RS13320 2754582..2754854 + 273 WP_003900544.1 hypothetical protein -
DPM14_RS13325 2754953..2755186 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2745009..2757005 11996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T107076 WP_003899414.1 NZ_CP030093:c2750009-2749686 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T107076 NZ_CP030093:c2750009-2749686 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT107076 WP_003899415.1 NZ_CP030093:c2750334-2750089 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT107076 NZ_CP030093:c2750334-2750089 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References