Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 519437..519953 Replicon chromosome
Accession NZ_CP030070
Organism Klebsiella pneumoniae strain IA565

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag DPF99_RS04665 Protein ID WP_009309309.1
Coordinates 519669..519953 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag DPF99_RS04660 Protein ID WP_002886901.1
Coordinates 519437..519679 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPF99_RS04645 515465..516205 + 741 WP_032417761.1 KDGP aldolase family protein -
DPF99_RS04650 516272..517426 + 1155 WP_002886900.1 lactonase family protein -
DPF99_RS04655 517449..519359 + 1911 WP_004152270.1 BglG family transcription antiterminator -
DPF99_RS04660 519437..519679 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DPF99_RS04665 519669..519953 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DPF99_RS04670 519957..520421 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DPF99_RS04675 520663..522801 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
DPF99_RS04680 523158..523901 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
DPF99_RS27420 523904..524077 - 174 WP_019725541.1 hypothetical protein -
DPF99_RS04685 524162..524470 + 309 WP_019725542.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T106975 WP_009309309.1 NZ_CP030070:519669-519953 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T106975 NZ_CP030070:519669-519953 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT106975 WP_002886901.1 NZ_CP030070:519437-519679 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT106975 NZ_CP030070:519437-519679 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References