Detailed information of TA system TA106869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1302931..1304482
• Replicon: chromosome
• Accession: NZ_CP030020
• Organism: Streptococcus suis strain ISU2514

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: DK875_RS06330
• Protein ID: WP_079739431.1
• Coordinates: 1302931..1304208 (-)
• Length: 426 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: R2XCR7
• Locus tag: DK875_RS06335
• Protein ID: WP_000301765.1
• Coordinates: 1304210..1304482 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK875_RS06310	1298019..1299830	-	1812	WP_014637055.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
DK875_RS06315	1300262..1301611	-	1350	WP_053866436.1	ISLre2 family transposase	-
DK875_RS06320	1301785..1302000	-	216	WP_053866437.1	hypothetical protein	-
DK875_RS06325	1302047..1302844	-	798	WP_053866438.1	AAA family ATPase	-
DK875_RS06330	1302931..1304208	-	1278	WP_079739431.1	zeta toxin family protein	Toxin
DK875_RS06335	1304210..1304482	-	273	WP_000301765.1	antitoxin	Antitoxin
DK875_RS06340	1304499..1304708	-	210	WP_000527318.1	peptide-binding protein	-
DK875_RS06345	1304807..1305703	-	897	WP_002334978.1	ParA family protein	-
DK875_RS06350	1305806..1306090	-	285	WP_074390291.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DK875_RS06355	1306236..1306973	-	738	WP_012477196.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
DK875_RS06360	1307098..1307193	-	96	WP_001809736.1	23S rRNA methyltransferase attenuation leader peptide	-
DK875_RS06365	1307269..1307610	-	342	Protein_1231	recombinase family protein	-
DK875_RS06370	1307962..1308279	-	318	WP_053866439.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B)	-	1300262..1330097	29835
	-	flank	IS/Tn	erm(B)	-	1306236..1310983	4747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-214)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 426 a.a.
• Molecular weight: 48802.57 Da
• Isoelectric Point: 9.0764

>T106869 WP_079739431.1 NZ_CP030020:c1304208-1302931 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKANKDRPQLQAMLAYIREGDIVVVTELERLGRNNKELTEVMNDIQAKGATLEVL
NLPTLRGIEDDNLRRLLNNLILELYKYQAQAERERIKERQRQGIAIAKTQGKYKGRKAIFSEDDSRLLHAFDLYLEGLSD
KDVAKLTGINERTFRRYREKHKIKR

Nucleotide

• Length: 1278 bp

>T106869 NZ_CP030020:c1304208-1302931 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAGCTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATATACGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AGCTAATAAAGACCGCCCTCAGTTACAAGCTATGCTTGCTTATATACGTGAAGGTGATATAGTGGTTGTGACAGAATTAG
AACGCCTGGGTAGGAATAACAAGGAGCTAACTGAGGTCATGAATGATATTCAAGCCAAGGGGGCAACCTTGGAAGTCTTA
AATCTTCCCACTCTTCGAGGGATTGAGGATGACAACCTGAGACGGCTCTTGAACAATCTTATCCTGGAACTCTACAAGTA
CCAGGCACAAGCTGAAAGGGAACGCATAAAGGAACGGCAACGCCAAGGGATAGCTATTGCCAAGACTCAAGGAAAGTACA
AAGGCAGAAAAGCCATTTTTTCAGAAGATGACAGCAGGCTTCTTCATGCCTTTGACCTTTACCTTGAAGGTCTATCAGAT
AAAGACGTTGCCAAGCTAACAGGTATCAACGAACGTACTTTTAGGCGGTATCGTGAAAAGCATAAGATAAAAAGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10721.25 Da
• Isoelectric Point: 6.4676

>AT106869 WP_000301765.1 NZ_CP030020:c1304482-1304210 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Nucleotide

• Length: 273 bp

>AT106869 NZ_CP030020:c1304482-1304210 [Streptococcus suis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829F0A3