Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2473301..2473918 Replicon chromosome
Accession NZ_CP029985
Organism Sphingomonas sp. FARSPH

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DM480_RS11870 Protein ID WP_115381248.1
Coordinates 2473553..2473918 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DM480_RS11865 Protein ID WP_115379295.1
Coordinates 2473301..2473534 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM480_RS11835 2468580..2468849 + 270 WP_115379284.1 HPr-rel-A system PqqD family peptide chaperone -
DM480_RS11840 2468846..2469700 + 855 WP_115379287.1 HprK-related kinase A -
DM480_RS11845 2469697..2470722 + 1026 WP_198665955.1 nucleotidyltransferase family protein -
DM480_RS11850 2470758..2471168 + 411 WP_125471513.1 hypothetical protein -
DM480_RS11855 2471175..2471861 - 687 WP_115379293.1 HAD-IA family hydrolase -
DM480_RS11860 2471923..2473275 + 1353 WP_115381246.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
DM480_RS11865 2473301..2473534 + 234 WP_115379295.1 ribbon-helix-helix domain-containing protein Antitoxin
DM480_RS11870 2473553..2473918 + 366 WP_115381248.1 type II toxin-antitoxin system VapC family toxin Toxin
DM480_RS11875 2473933..2475756 + 1824 WP_115379297.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
DM480_RS11880 2475828..2476742 + 915 WP_115381250.1 ROK family protein -
DM480_RS11885 2476790..2478718 + 1929 WP_115379299.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-39)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13554.71 Da        Isoelectric Point: 6.7260

>T106831 WP_115381248.1 NZ_CP029985:2473553-2473918 [Sphingomonas sp. FARSPH]
VAQPFFDTNILIDWLLDRPQASEELARYASHRISRIVWTEILAGEPQAQRPTIHRLLSGFEIVEIDAQIAAAAADIRFDT
RMKLLDAMILATARVHGAMLISRNTKDFPAGMPGVRVPYTL

Download         Length: 366 bp

>T106831 NZ_CP029985:2473553-2473918 [Sphingomonas sp. FARSPH]
GTGGCCCAGCCTTTCTTCGACACGAACATCCTGATCGATTGGTTACTGGATCGCCCGCAGGCCAGCGAGGAGCTGGCGCG
TTATGCGAGCCATCGGATAAGCCGGATAGTCTGGACGGAGATACTGGCTGGCGAGCCGCAGGCGCAGCGGCCCACTATTC
ATAGGCTTTTGTCCGGGTTCGAAATCGTCGAGATCGACGCGCAAATCGCGGCGGCGGCGGCGGATATACGGTTCGATACG
CGCATGAAATTGTTGGACGCTATGATCCTGGCGACGGCGCGCGTCCACGGCGCCATGCTGATCTCTCGCAATACGAAGGA
TTTTCCGGCAGGCATGCCGGGCGTCCGTGTCCCCTATACCCTCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9186.29 Da        Isoelectric Point: 8.6372

>AT106831 WP_115379295.1 NZ_CP029985:2473301-2473534 [Sphingomonas sp. FARSPH]
MRTLIDLPDRDIERLDALARQRKVSRASLIRQAVERHLNDNDANGWIRRGAGYWRNRDDIGDPIEYQRVMREDRDPV

Download         Length: 234 bp

>AT106831 NZ_CP029985:2473301-2473534 [Sphingomonas sp. FARSPH]
ATGCGTACGTTGATCGATCTTCCGGACCGTGACATCGAGCGGCTCGATGCACTGGCGCGTCAACGCAAAGTGTCGCGCGC
CTCGTTGATCCGCCAGGCCGTGGAGCGTCACCTCAACGACAACGATGCTAACGGCTGGATTCGGCGTGGGGCGGGCTATT
GGCGGAATCGCGACGACATCGGCGATCCGATCGAATATCAGCGCGTCATGCGTGAAGATCGTGACCCGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References