Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4512645..4513479 Replicon chromosome
Accession NZ_CP029981
Organism Escherichia coli strain 99-3165

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag B4O06_RS24820 Protein ID WP_000854727.1
Coordinates 4512645..4513022 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag B4O06_RS24825 Protein ID WP_024183700.1
Coordinates 4513111..4513479 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4O06_RS24780 4508760..4509457 - 698 Protein_4311 IS1 family transposase -
B4O06_RS24790 4509513..4509896 - 384 Protein_4312 integrase arm-type DNA-binding domain-containing protein -
B4O06_RS24795 4510342..4510668 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
B4O06_RS24800 4510665..4510928 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
B4O06_RS24805 4511000..4511866 - 867 WP_001280426.1 DUF4942 domain-containing protein -
B4O06_RS24810 4511951..4512148 - 198 WP_000839291.1 DUF957 domain-containing protein -
B4O06_RS24815 4512160..4512648 - 489 WP_032328344.1 hypothetical protein -
B4O06_RS24820 4512645..4513022 - 378 WP_000854727.1 TA system toxin CbtA family protein Toxin
B4O06_RS24825 4513111..4513479 - 369 WP_024183700.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B4O06_RS24830 4513559..4513780 - 222 WP_000692295.1 DUF987 domain-containing protein -
B4O06_RS24835 4513849..4514325 - 477 WP_032328266.1 RadC family protein -
B4O06_RS24840 4514340..4514825 - 486 WP_000206660.1 antirestriction protein -
B4O06_RS24845 4514917..4515735 - 819 WP_001234693.1 DUF945 domain-containing protein -
B4O06_RS24855 4515834..4516067 - 234 WP_001278281.1 DUF905 family protein -
B4O06_RS26910 4516073..4516450 - 378 WP_172902802.1 hypothetical protein -
B4O06_RS26915 4516490..4516750 - 261 WP_172902803.1 hypothetical protein -
B4O06_RS24865 4516869..4517753 - 885 WP_000010388.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4489886..4516750 26864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14345.39 Da        Isoelectric Point: 9.2442

>T106822 WP_000854727.1 NZ_CP029981:c4513022-4512645 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T106822 NZ_CP029981:c4513022-4512645 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13617.41 Da        Isoelectric Point: 7.7474

>AT106822 WP_024183700.1 NZ_CP029981:c4513479-4513111 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT106822 NZ_CP029981:c4513479-4513111 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAATTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References