Detailed information of TA system TA106807

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1153886..1154720
• Replicon: chromosome
• Accession: NZ_CP029981
• Organism: Escherichia coli strain 99-3165

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: B4O06_RS07125
• Protein ID: WP_140159973.1
• Coordinates: 1153886..1154254 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: B4O06_RS07130
• Protein ID: WP_001285580.1
• Coordinates: 1154352..1154720 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4O06_RS07095	1149013..1150161	-	1149	WP_000905925.1	capsule polysaccharide transporter	-
B4O06_RS07100	1150233..1151216	-	984	WP_001355482.1	KpsF/GutQ family sugar-phosphate isomerase	-
B4O06_RS07105	1152027..1152197	-	171	Protein_1083	IS110 family transposase	-
B4O06_RS07110	1152540..1153382	-	843	WP_001280493.1	DUF4942 domain-containing protein	-
B4O06_RS07115	1153467..1153664	-	198	WP_023563519.1	DUF957 domain-containing protein	-
B4O06_RS07120	1153740..1153889	-	150	Protein_1086	hypothetical protein	-
B4O06_RS07125	1153886..1154254	-	369	WP_140159973.1	TA system toxin CbtA family protein	Toxin
B4O06_RS07130	1154352..1154720	-	369	WP_001285580.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
B4O06_RS07135	1154799..1155020	-	222	WP_000691818.1	DUF987 domain-containing protein	-
B4O06_RS07145	1155157..1155336	-	180	WP_001398324.1	hypothetical protein	-
B4O06_RS07150	1155378..1156075	+	698	Protein_1091	IS1 family transposase	-
B4O06_RS07155	1156884..1157108	+	225	WP_001395295.1	transposase	-
B4O06_RS07160	1157110..1157241	-	132	Protein_1093	integrase core domain-containing protein	-
B4O06_RS07165	1157273..1158844	-	1572	WP_000381401.1	IS66 family transposase	-
B4O06_RS07170	1158864..1159211	-	348	WP_000624622.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	kpsF	1150233..1171863	21630

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-109)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13616.51 Da
• Isoelectric Point: 9.1652

>T106807 WP_140159973.1 NZ_CP029981:c1154254-1153886 [Escherichia coli]
ITQHTRTGGIARPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVSFLVEKYALVRTDQPGFSAC
TRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 369 bp

>T106807 NZ_CP029981:c1154254-1153886 [Escherichia coli]
ATTACCCAACACACACGTACGGGAGGCATCGCGCGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTCCCGGTTGCT
GGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTGAAGCTGGCA
TTTCACTGTGTGATGCGGTGAGCTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTCAGCGCCTGT
ACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGACAACTACAG
AACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13670.43 Da
• Isoelectric Point: 6.9462

>AT106807 WP_001285580.1 NZ_CP029981:c1154720-1154352 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADSYHLNQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT106807 NZ_CP029981:c1154720-1154352 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA