Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 357038..357873 Replicon chromosome
Accession NZ_CP029981
Organism Escherichia coli strain 99-3165

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag B4O06_RS02895 Protein ID WP_000854743.1
Coordinates 357038..357415 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag B4O06_RS02900 Protein ID WP_001285298.1
Coordinates 357505..357873 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4O06_RS02860 352395..353318 - 924 WP_032328268.1 carboxylate/amino acid/amine transporter -
B4O06_RS02865 353429..354613 - 1185 WP_001172882.1 sugar efflux transporter -
B4O06_RS02880 355409..356247 - 839 Protein_310 DUF4942 domain-containing protein -
B4O06_RS02885 356344..356541 - 198 WP_000839275.1 DUF957 domain-containing protein -
B4O06_RS02890 356553..357041 - 489 WP_000761693.1 hypothetical protein -
B4O06_RS02895 357038..357415 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
B4O06_RS02900 357505..357873 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B4O06_RS02905 357923..358567 - 645 WP_000086754.1 hypothetical protein -
B4O06_RS02910 358586..358807 - 222 WP_000692295.1 DUF987 domain-containing protein -
B4O06_RS02915 358876..359352 - 477 WP_032328266.1 RadC family protein -
B4O06_RS26780 359367..359642 - 276 Protein_318 antirestriction protein -
B4O06_RS02920 359637..361340 - 1704 Protein_319 autotransporter adhesin family protein -
B4O06_RS02925 361712..362584 - 873 WP_001069707.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T106803 WP_000854743.1 NZ_CP029981:c357415-357038 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T106803 NZ_CP029981:c357415-357038 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT106803 WP_001285298.1 NZ_CP029981:c357873-357505 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT106803 NZ_CP029981:c357873-357505 [Escherichia coli]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References