Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4105699..4106300 Replicon chromosome
Accession NZ_CP029715
Organism Serratia marcescens strain AR_0131

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag AM378_RS19495 Protein ID WP_033649548.1
Coordinates 4105699..4106079 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag AM378_RS19500 Protein ID WP_004933932.1
Coordinates 4106079..4106300 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM378_RS19470 4100952..4102232 + 1281 WP_033649550.1 DUF3748 domain-containing protein -
AM378_RS19475 4102263..4102610 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
AM378_RS19480 4102921..4103334 + 414 WP_004933919.1 heat shock chaperone IbpA -
AM378_RS19485 4103435..4103863 + 429 WP_004933922.1 heat shock chaperone IbpB -
AM378_RS19490 4104030..4105688 + 1659 WP_033649549.1 putative transporter -
AM378_RS19495 4105699..4106079 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
AM378_RS19500 4106079..4106300 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
AM378_RS19505 4106375..4107625 - 1251 WP_033649547.1 valine--pyruvate transaminase -
AM378_RS19510 4107761..4109824 - 2064 WP_048321223.1 alpha-amylase -
AM378_RS24630 4110021..4110173 + 153 WP_019455508.1 hypothetical protein -
AM378_RS19515 4110175..4111152 - 978 WP_033636542.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T106497 WP_033649548.1 NZ_CP029715:c4106079-4105699 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T106497 NZ_CP029715:c4106079-4105699 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGTATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT106497 WP_004933932.1 NZ_CP029715:c4106300-4106079 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT106497 NZ_CP029715:c4106300-4106079 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References