Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3403784..3404379 Replicon chromosome
Accession NZ_CP029715
Organism Serratia marcescens strain AR_0131

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AM378_RS16245 Protein ID WP_072071906.1
Coordinates 3404125..3404379 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM378_RS16240 Protein ID WP_033633573.1
Coordinates 3403784..3404125 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM378_RS16225 3399975..3400790 - 816 WP_048321965.1 GPO family capsid scaffolding protein -
AM378_RS16230 3400933..3402705 + 1773 WP_033632041.1 terminase ATPase subunit family protein -
AM378_RS16235 3402705..3403739 + 1035 WP_048321966.1 phage portal protein -
AM378_RS16240 3403784..3404125 - 342 WP_033633573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM378_RS16245 3404125..3404379 - 255 WP_072071906.1 type II toxin-antitoxin system HicA family toxin Toxin
AM378_RS16250 3404764..3405846 - 1083 WP_072071907.1 restriction endonuclease -
AM378_RS16255 3405843..3407639 - 1797 WP_072071908.1 type I restriction-modification system subunit M -
AM378_RS16260 3407800..3408012 - 213 WP_072071909.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-Ic rfaE 3363276..3418532 55256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9526.00 Da        Isoelectric Point: 11.1073

>T106496 WP_072071906.1 NZ_CP029715:c3404379-3404125 [Serratia marcescens]
MNKRHQKTLSDVFTRPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

>T106496 NZ_CP029715:c3404379-3404125 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTACCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12399.90 Da        Isoelectric Point: 4.5789

>AT106496 WP_033633573.1 NZ_CP029715:c3404125-3403784 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 342 bp

>AT106496 NZ_CP029715:c3404125-3403784 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCTATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References