Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 513929..514482 Replicon chromosome
Accession NZ_CP029715
Organism Serratia marcescens strain AR_0131

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2V4FZ31
Locus tag AM378_RS02580 Protein ID WP_019454426.1
Coordinates 514168..514482 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2V4GJ62
Locus tag AM378_RS02575 Protein ID WP_029988820.1
Coordinates 513929..514165 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM378_RS02560 510396..511931 + 1536 WP_033646792.1 glutathione ABC transporter substrate-binding protein GsiB -
AM378_RS02565 511984..512904 + 921 WP_033646790.1 glutathione ABC transporter permease GsiC -
AM378_RS02570 512914..513822 + 909 WP_172448764.1 glutathione ABC transporter permease GsiD -
AM378_RS02575 513929..514165 + 237 WP_029988820.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
AM378_RS02580 514168..514482 + 315 WP_019454426.1 CcdB family protein Toxin
AM378_RS02585 514522..515364 - 843 WP_015377214.1 S-formylglutathione hydrolase -
AM378_RS02590 515379..516503 - 1125 WP_033646788.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
AM378_RS02595 516534..517454 - 921 WP_016928453.1 LysR family transcriptional regulator -
AM378_RS02600 517560..518717 + 1158 WP_033646786.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11745.68 Da        Isoelectric Point: 5.0488

>T106482 WP_019454426.1 NZ_CP029715:514168-514482 [Serratia marcescens]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Download         Length: 315 bp

>T106482 NZ_CP029715:514168-514482 [Serratia marcescens]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCGGGGAGTACGCGACCGGAACGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9082.13 Da        Isoelectric Point: 5.7070

>AT106482 WP_029988820.1 NZ_CP029715:513929-514165 [Serratia marcescens]
MPVKQRTTQSVTMTLERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp

>AT106482 NZ_CP029715:513929-514165 [Serratia marcescens]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGCTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGCGCGACGCTAACTGCTGCTTTAGATGCTGAGTTACGTCAGCATGAGAGGATAAAATGGCAGGAAGAAA
ACCGAGAGGCGCTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FZ31

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GJ62

References