Detailed information of TA system TA106220

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 153992..154330
• Replicon: chromosome
• Accession: NZ_CP029669
• Organism: Staphylococcus aureus strain AR_0223

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSB79_RS00935
• Protein ID: WP_011447039.1
• Coordinates: 153992..154168 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	154156..154330 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB79_RS00915	149227..153012	+	3786	WP_000582165.1	hypothetical protein	-
CSB79_RS00920	153002..153154	+	153	WP_001153681.1	hypothetical protein	-
CSB79_RS00925	153201..153488	+	288	WP_001040261.1	hypothetical protein	-
CSB79_RS00930	153546..153842	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSB79_RS00935	153992..154168	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	154156..154330	-	175	-	-	Antitoxin
CSB79_RS00945	154380..154634	+	255	WP_000611512.1	phage holin	-
CSB79_RS00950	154646..155401	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSB79_RS00955	155592..156083	+	492	WP_000919350.1	staphylokinase	-
CSB79_RS00965	156733..157068	+	336	Protein_177	SH3 domain-containing protein	-
CSB79_RS00970	157163..157612	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSB79_RS00975	158297..158647	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSB79_RS00980	158700..158960	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	102699..158647	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106220 WP_011447039.1 NZ_CP029669:153992-154168 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106220 NZ_CP029669:153992-154168 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT106220 NZ_CP029669:c154330-154156 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin