Detailed information of TA system TA105990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3888820..3889454
• Replicon: chromosome
• Accession: NZ_CP029601
• Organism: Streptomyces sp. WAC 01438

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DLM49_RS17295
• Protein ID: WP_125505197.1
• Coordinates: 3889032..3889454 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2T5B9U3
• Locus tag: DLM49_RS17290
• Protein ID: WP_020113663.1
• Coordinates: 3888820..3889035 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLM49_RS17275	3884570..3886492	-	1923	WP_125505195.1	ATP-dependent endonuclease	-
DLM49_RS17285	3887589..3888428	-	840	WP_125505196.1	SDR family NAD(P)-dependent oxidoreductase	-
DLM49_RS17290	3888820..3889035	+	216	WP_020113663.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DLM49_RS17295	3889032..3889454	+	423	WP_125505197.1	PIN domain nuclease	Toxin
DLM49_RS17300	3889501..3890112	-	612	WP_125505198.1	TetR/AcrR family transcriptional regulator	-
DLM49_RS17305	3890187..3890954	+	768	WP_125505199.1	SDR family oxidoreductase	-
DLM49_RS17310	3891042..3891257	-	216	WP_125505200.1	hypothetical protein	-
DLM49_RS17315	3891454..3892698	-	1245	WP_185930936.1	PucR family transcriptional regulator	-
DLM49_RS17320	3893064..3893909	+	846	WP_206302302.1	DUF4394 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-49)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15431.32 Da
• Isoelectric Point: 4.7039

>T105990 WP_125505197.1 NZ_CP029601:3889032-3889454 [Streptomyces sp. WAC 01438]
VNSAQYLIDTSALARMLRGDAEQYGWDRAAAAGLIATCPITELEFFYSARSAADRAQGIEDMRLLFGWVPVDDRAYDRAW
RVQDLLTQRGQHRSAGAVDLVVAATAELQGLTLLHRDRDFDCIAAVTGQALQWYGPEAGK

Nucleotide

• Length: 423 bp

>T105990 NZ_CP029601:3889032-3889454 [Streptomyces sp. WAC 01438]
GTGAACTCTGCGCAGTATCTGATCGACACCAGCGCGCTCGCCCGTATGCTGCGCGGCGACGCGGAGCAGTACGGATGGGA
CCGGGCGGCCGCCGCCGGGCTCATCGCCACCTGCCCCATCACCGAGCTGGAGTTCTTCTACAGCGCACGTTCCGCCGCCG
ACCGCGCACAGGGCATCGAAGACATGCGCCTGCTCTTCGGCTGGGTGCCGGTCGACGACCGTGCCTACGACCGCGCCTGG
CGGGTCCAGGACCTGCTCACCCAGCGCGGACAGCACCGCAGCGCCGGAGCCGTCGACCTCGTCGTGGCTGCCACGGCCGA
GTTGCAGGGCCTGACACTGCTCCACCGCGACCGGGACTTCGATTGCATCGCCGCCGTCACCGGCCAGGCGCTCCAGTGGT
ACGGCCCCGAAGCCGGGAAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7995.02 Da
• Isoelectric Point: 6.3273

>AT105990 WP_020113663.1 NZ_CP029601:3888820-3889035 [Streptomyces sp. WAC 01438]
MSRTVIDLDDQLVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRASAEEGAFDLDLFEDKGNYRR

Nucleotide

• Length: 216 bp

>AT105990 NZ_CP029601:3888820-3889035 [Streptomyces sp. WAC 01438]
ATGAGTCGAACCGTGATCGACCTCGACGACCAACTGGTCGCGGACGTGGCGAAGGCCCTCGGCACCAGCACCAAGAAGGA
GACGGTGAACACCGCCCTGCGCGAGGTGCTGGAGAACCGGCGGCGAGCCCTGGCGCTCACCCGCCTTCGGGCGTCGGCGG
AAGAGGGCGCCTTCGACCTCGATCTCTTCGAGGACAAAGGAAACTACCGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2T5B9U3