Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3443770..3444604 Replicon chromosome
Accession NZ_CP029579
Organism Escherichia coli strain DA33137

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag DLJ64_RS17825 Protein ID WP_000854688.1
Coordinates 3443770..3444147 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag DLJ64_RS17830 Protein ID WP_001285596.1
Coordinates 3444224..3444604 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ64_RS17790 3439318..3440252 - 935 Protein_3212 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DLJ64_RS17795 3440245..3440640 - 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
DLJ64_RS17800 3440709..3441554 - 846 WP_001280441.1 DUF4942 domain-containing protein -
DLJ64_RS17810 3441838..3442857 - 1020 WP_000875213.1 IS110 family transposase -
DLJ64_RS17815 3443071..3443268 - 198 WP_000839260.1 DUF957 domain-containing protein -
DLJ64_RS17820 3443285..3443773 - 489 WP_000761701.1 hypothetical protein -
DLJ64_RS17825 3443770..3444147 - 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
DLJ64_RS17830 3444224..3444604 - 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DLJ64_RS17835 3444654..3445298 - 645 WP_000094917.1 hypothetical protein -
DLJ64_RS17840 3445317..3445538 - 222 WP_000692329.1 DUF987 domain-containing protein -
DLJ64_RS17845 3445601..3446077 - 477 WP_001186726.1 RadC family protein -
DLJ64_RS17850 3446093..3446578 - 486 WP_000849564.1 antirestriction protein -
DLJ64_RS17855 3446633..3447451 - 819 WP_001234616.1 DUF945 domain-containing protein -
DLJ64_RS17865 3447552..3447785 - 234 WP_001119727.1 DUF905 family protein -
DLJ64_RS17870 3447864..3448319 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T105888 WP_000854688.1 NZ_CP029579:c3444147-3443770 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T105888 NZ_CP029579:c3444147-3443770 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT105888 WP_001285596.1 NZ_CP029579:c3444604-3444224 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT105888 NZ_CP029579:c3444604-3444224 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References