Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1571958..1572789 Replicon chromosome
Accession NZ_CP029576
Organism Escherichia coli strain DA33135

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag DLJ63_RS07970 Protein ID WP_000854814.1
Coordinates 1571958..1572332 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag DLJ63_RS07975 Protein ID WP_001546021.1
Coordinates 1572421..1572789 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ63_RS07935 1567953..1568282 + 330 WP_000450409.1 DUF496 family protein -
DLJ63_RS07940 1568383..1568565 - 183 WP_001016348.1 hypothetical protein -
DLJ63_RS07945 1568619..1568765 + 147 Protein_1443 transposase domain-containing protein -
DLJ63_RS07950 1568976..1570517 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
DLJ63_RS07955 1570532..1571278 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
DLJ63_RS07960 1571641..1571754 - 114 WP_001161660.1 DUF957 domain-containing protein -
DLJ63_RS07965 1571767..1571961 - 195 WP_000988601.1 hypothetical protein -
DLJ63_RS07970 1571958..1572332 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
DLJ63_RS07975 1572421..1572789 - 369 WP_001546021.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
DLJ63_RS07980 1572869..1573090 - 222 WP_000692323.1 DUF987 domain-containing protein -
DLJ63_RS07985 1573153..1573629 - 477 WP_001186773.1 RadC family protein -
DLJ63_RS07990 1573645..1574118 - 474 WP_001385393.1 antirestriction protein -
DLJ63_RS07995 1574381..1575202 - 822 WP_001234710.1 DUF945 domain-containing protein -
DLJ63_RS08005 1575423..1575833 - 411 WP_000846704.1 hypothetical protein -
DLJ63_RS08010 1575849..1576526 - 678 WP_001362823.1 hypothetical protein -
DLJ63_RS08015 1576662..1577732 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T105832 WP_000854814.1 NZ_CP029576:c1572332-1571958 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T105832 NZ_CP029576:c1572332-1571958 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT105832 WP_001546021.1 NZ_CP029576:c1572789-1572421 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT105832 NZ_CP029576:c1572789-1572421 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References