Detailed information of TA system TA105772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 61451..61943
• Replicon: chromosome
• Accession: NZ_CP029559
• Organism: Streptococcus sobrinus strain NIDR 6715-15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DLJ52_RS00355
• Protein ID: WP_109982349.1
• Coordinates: 61677..61943 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DLJ52_RS00350
• Protein ID: WP_109982348.1
• Coordinates: 61451..61684 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ52_RS00330	56603..58150	+	1548	WP_109982346.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-
DLJ52_RS00335	58354..58893	-	540	WP_002959581.1	TetR/AcrR family transcriptional regulator	-
DLJ52_RS00340	59046..59567	+	522	WP_019769995.1	HXXEE domain-containing protein	-
DLJ52_RS00345	59893..61080	+	1188	WP_109982347.1	LysM peptidoglycan-binding domain-containing protein	-
DLJ52_RS00350	61451..61684	+	234	WP_109982348.1	RelB protein	Antitoxin
DLJ52_RS00355	61677..61943	+	267	WP_109982349.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DLJ52_RS00360	61998..63812	+	1815	WP_109982350.1	hypothetical protein	-
DLJ52_RS00365	63972..65231	+	1260	WP_109982351.1	phosphoribosylamine--glycine ligase	-
DLJ52_RS00370	65228..65671	+	444	WP_019783927.1	DUF523 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10135.99 Da
• Isoelectric Point: 10.5049

>T105772 WP_109982349.1 NZ_CP029559:61677-61943 [Streptococcus sobrinus]
MYKLVLSKAFIKQLSKLDKYTANSILVWLEKNIDGLDNPRQKGKALVGDLKGLWRYRVGNYRVICQIKDDQLVVVAVSGG
HRKEIYKK

Nucleotide

• Length: 267 bp

>T105772 NZ_CP029559:61677-61943 [Streptococcus sobrinus]
ATGTATAAACTGGTTTTATCGAAAGCATTCATTAAGCAATTAAGCAAGCTCGACAAATACACAGCTAACTCCATTTTAGT
TTGGCTCGAAAAGAACATTGATGGCCTAGATAATCCCAGACAAAAAGGCAAGGCCTTGGTCGGCGATTTAAAAGGGCTCT
GGCGCTACCGCGTTGGCAATTACCGAGTCATCTGCCAAATCAAAGACGACCAGCTAGTAGTTGTCGCTGTCAGCGGCGGA
CATCGCAAAGAAATCTATAAGAAGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8595.65 Da
• Isoelectric Point: 4.1948

>AT105772 WP_109982348.1 NZ_CP029559:61451-61684 [Streptococcus sobrinus]
MPVISLRLNKEEEIFFKNYAHFTGKSLSELFKNALAEEIENQLDYKLGAEGVQALEADGGQTYSIAEARDMLGLDNV

Nucleotide

• Length: 234 bp

>AT105772 NZ_CP029559:61451-61684 [Streptococcus sobrinus]
ATGCCCGTTATTTCATTACGACTGAATAAAGAAGAGGAAATCTTCTTCAAAAATTATGCACATTTCACTGGTAAAAGTTT
GTCAGAGCTTTTCAAAAATGCCTTGGCTGAAGAAATAGAAAATCAATTAGATTATAAGCTGGGTGCTGAGGGGGTACAAG
CCTTAGAAGCGGACGGCGGTCAAACCTACTCTATCGCAGAAGCGCGTGATATGCTTGGGTTAGACAATGTATAA