Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 955253..955907 Replicon chromosome
Accession NZ_CP029242
Organism Escherichia coli strain ECCRA-119

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag C7235_RS05155 Protein ID WP_000244772.1
Coordinates 955500..955907 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C7235_RS05150 Protein ID WP_000354046.1
Coordinates 955253..955519 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7235_RS05125 950422..951165 + 744 WP_000951941.1 SDR family oxidoreductase -
C7235_RS05130 951222..952655 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
C7235_RS05135 952700..953011 + 312 WP_001182945.1 N(4)-acetylcytidine aminohydrolase -
C7235_RS05140 953175..953834 + 660 WP_000250274.1 hemolysin III family protein -
C7235_RS05145 954030..955010 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
C7235_RS05150 955253..955519 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C7235_RS05155 955500..955907 + 408 WP_000244772.1 protein YgfX Toxin
C7235_RS05160 955947..956468 - 522 WP_001055874.1 flavodoxin FldB -
C7235_RS05165 956580..957476 + 897 WP_000806637.1 site-specific tyrosine recombinase XerD -
C7235_RS05170 957501..958211 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C7235_RS05175 958217..959950 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T105316 WP_000244772.1 NZ_CP029242:955500-955907 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T105316 NZ_CP029242:955500-955907 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT105316 WP_000354046.1 NZ_CP029242:955253-955519 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT105316 NZ_CP029242:955253-955519 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References