Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2844107..2844636 Replicon chromosome
Accession NZ_CP029190
Organism Streptomyces venezuelae strain ATCC 21782

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DEJ50_RS12370 Protein ID WP_150207871.1
Coordinates 2844379..2844636 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DEJ50_RS12365 Protein ID WP_150207869.1
Coordinates 2844107..2844382 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEJ50_RS12350 2840195..2841166 - 972 WP_150207864.1 LysR family transcriptional regulator -
DEJ50_RS12355 2841264..2842565 + 1302 WP_150207866.1 MFS transporter -
DEJ50_RS12360 2842778..2844019 + 1242 WP_150207868.1 SH3 domain-containing protein -
DEJ50_RS12365 2844107..2844382 + 276 WP_150207869.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DEJ50_RS12370 2844379..2844636 + 258 WP_150207871.1 Txe/YoeB family addiction module toxin Toxin
DEJ50_RS12375 2844814..2845791 - 978 WP_150207873.1 hypothetical protein -
DEJ50_RS12380 2845875..2846105 + 231 WP_150207875.1 antitoxin -
DEJ50_RS12385 2846102..2846512 + 411 WP_150207877.1 type II toxin-antitoxin system VapC family toxin -
DEJ50_RS12395 2847035..2847520 - 486 WP_150207879.1 SsrA-binding protein SmpB -
DEJ50_RS12400 2847539..2848741 - 1203 WP_150207881.1 PDZ domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10132.59 Da        Isoelectric Point: 9.4585

>T105189 WP_150207871.1 NZ_CP029190:2844379-2844636 [Streptomyces venezuelae]
VRSIHFDPAAWEDFLFWLASDVKMARRITRLIGEIQRDPFSGIGKPEPLKGDLSGYWSRRIDDEHRLVYRADEKEVKILK
ARYHY

Download         Length: 258 bp

>T105189 NZ_CP029190:2844379-2844636 [Streptomyces venezuelae]
GTGAGGAGTATCCACTTCGACCCGGCCGCCTGGGAGGACTTCCTGTTCTGGCTCGCTTCCGACGTGAAGATGGCCCGCAG
GATCACCCGCCTCATCGGCGAGATCCAGCGCGACCCGTTCAGCGGGATCGGCAAGCCCGAGCCACTGAAGGGCGACCTGT
CGGGCTATTGGTCCCGCCGGATCGACGACGAGCACCGGCTCGTCTACCGGGCGGACGAGAAGGAAGTGAAGATCCTGAAG
GCCCGCTACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10054.20 Da        Isoelectric Point: 4.3766

>AT105189 WP_150207869.1 NZ_CP029190:2844107-2844382 [Streptomyces venezuelae]
MSISASEARATLFPLIERVNTDHAPVRITSKNGDAVLMSADDYDSWQETVYLLRSPANAQRLMEAVARDRESAPEVTKSM
DELRELTGGEA

Download         Length: 276 bp

>AT105189 NZ_CP029190:2844107-2844382 [Streptomyces venezuelae]
ATGTCCATAAGCGCCAGCGAAGCCCGGGCCACGCTCTTCCCGCTCATCGAGCGTGTCAACACCGACCACGCCCCGGTGCG
CATCACCTCCAAGAACGGCGACGCCGTCCTCATGTCCGCCGACGACTACGACTCCTGGCAGGAGACCGTCTACCTGCTCC
GCTCCCCGGCCAATGCCCAGCGGCTGATGGAGGCCGTGGCCCGTGACCGGGAGAGCGCGCCCGAGGTCACCAAGAGCATG
GACGAGCTGAGGGAGCTCACGGGGGGCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References