Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3797377..3797969 Replicon chromosome
Accession NZ_CP029128
Organism Klebsiella oxytoca strain AR380

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag CSC17_RS18815 Protein ID WP_004105955.1
Coordinates 3797595..3797969 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag CSC17_RS18810 Protein ID WP_004105957.1
Coordinates 3797377..3797598 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC17_RS18790 3792938..3793492 + 555 WP_004105965.1 YgjV family protein -
CSC17_RS18795 3793507..3794754 - 1248 WP_004105963.1 serine/threonine transporter SstT -
CSC17_RS18800 3795009..3795977 - 969 WP_004115718.1 TerC family protein -
CSC17_RS18805 3796228..3797217 - 990 WP_070556310.1 Gfo/Idh/MocA family oxidoreductase -
CSC17_RS18810 3797377..3797598 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CSC17_RS18815 3797595..3797969 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CSC17_RS18820 3797949..3798452 - 504 WP_070556312.1 M48 family metallopeptidase -
CSC17_RS18825 3798531..3800174 - 1644 WP_004115710.1 glycoside hydrolase family 43 protein -
CSC17_RS18830 3800303..3801169 - 867 WP_004105950.1 AraC family transcriptional regulator -
CSC17_RS18835 3801277..3802620 + 1344 WP_004105949.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T105012 WP_004105955.1 NZ_CP029128:3797595-3797969 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T105012 NZ_CP029128:3797595-3797969 [Klebsiella oxytoca]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTAGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT105012 WP_004105957.1 NZ_CP029128:3797377-3797598 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT105012 NZ_CP029128:3797377-3797598 [Klebsiella oxytoca]
ATGCGCTCTTATAGTACATCTGAAGCCAGACAGAATATTGCGGCCGTCATGGACGCCGCTGCCAGCGGAGAACCGATTGA
AATTACGCGGCGTGATGGAACGTCTAATGTTTTGATCAGTAAGGCTGAATATGAAACGTTTATGAATGCCAAACTTGATG
CGGAGTTTGATTTTATTATGCAGCGACACGGCCGTACAGTTAAGGCGTTGACCGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References