Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 79990..80495 Replicon chromosome
Accession NZ_CP029097
Organism Pseudomonas aeruginosa strain AR439

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag CSC26_RS02955 Protein ID WP_003121619.1
Coordinates 80214..80495 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CSC26_RS02950 Protein ID WP_003083775.1
Coordinates 79990..80217 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC26_RS02925 75008..76501 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
CSC26_RS02930 76670..78097 + 1428 WP_003083784.1 GABA permease -
CSC26_RS02935 78179..78520 - 342 WP_003101229.1 alkylphosphonate utilization protein -
CSC26_RS02940 78593..79093 - 501 WP_003101228.1 LEA type 2 family protein -
CSC26_RS02945 79194..79814 + 621 WP_003101226.1 hypothetical protein -
CSC26_RS02950 79990..80217 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CSC26_RS02955 80214..80495 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
CSC26_RS02960 80795..81703 + 909 WP_023083551.1 LysR family transcriptional regulator -
CSC26_RS02965 81735..82121 - 387 WP_014602345.1 aegerolysin family protein -
CSC26_RS02970 82325..83059 - 735 WP_003117208.1 GntR family transcriptional regulator -
CSC26_RS02975 83160..83846 - 687 WP_003083762.1 FadR family transcriptional regulator -
CSC26_RS02980 83895..85244 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T104845 WP_003121619.1 NZ_CP029097:80214-80495 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T104845 NZ_CP029097:80214-80495 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT104845 WP_003083775.1 NZ_CP029097:79990-80217 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT104845 NZ_CP029097:79990-80217 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References