Detailed information of TA system TA104773

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2193585..2194164
• Replicon: chromosome
• Accession: NZ_CP029082
• Organism: Staphylococcus aureus strain AR465

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC50_RS11830
• Protein ID: WP_001025401.1
• Coordinates: 2193585..2193830 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2193799..2194164 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC50_RS11790	2189699..2190313	+	615	WP_000191464.1	hypothetical protein	-
CSC50_RS11795	2190310..2190456	-	147	WP_001795334.1	hypothetical protein	-
CSC50_RS11800	2190493..2190675	-	183	WP_000705240.1	hypothetical protein	-
CSC50_RS11805	2190771..2191691	-	921	WP_000348133.1	3'-5' exoribonuclease	-
CSC50_RS11810	2191707..2192321	-	615	WP_000801423.1	XRE family transcriptional regulator	-
CSC50_RS11815	2192493..2192720	+	228	WP_001030311.1	hypothetical protein	-
CSC50_RS11820	2192746..2193301	+	556	Protein_2146	phage antirepressor KilAC domain-containing protein	-
CSC50_RS11825	2193317..2193535	+	219	WP_001001383.1	hypothetical protein	-
CSC50_RS11830	2193585..2193830	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC50_RS11835	2193799..2194164	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC50_RS11840	2194219..2194434	+	216	WP_001097552.1	hypothetical protein	-
CSC50_RS11845	2194459..2194722	+	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
CSC50_RS11850	2194735..2194896	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC50_RS11855	2194975..2195298	+	324	WP_000174998.1	hypothetical protein	-
CSC50_RS11860	2195313..2195675	+	363	WP_000985971.1	hypothetical protein	-
CSC50_RS11865	2195672..2196838	+	1167	WP_000762530.1	DUF2800 domain-containing protein	-
CSC50_RS11870	2196864..2197421	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2185379..2234103	48724

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T104773 WP_001025401.1 NZ_CP029082:2193585-2193830 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T104773 NZ_CP029082:2193585-2193830 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT104773 NZ_CP029082:c2194164-2193799 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin