104725

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2950818..2951466 Replicon chromosome
Accession NZ_CP029065
Organism Mycobacterium tuberculosis strain TBMENG-03

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag DDF83_RS14520 Protein ID WP_003903987.1
Coordinates 2950818..2951141 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag DDF83_RS14525 Protein ID WP_003899415.1
Coordinates 2951221..2951466 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDF83_RS14490 2946141..2947139 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
DDF83_RS14495 2947153..2947617 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
DDF83_RS14500 2947605..2947856 + 252 WP_003908028.1 hypothetical protein -
DDF83_RS14505 2948027..2949466 - 1440 WP_003901443.1 phage major capsid protein -
DDF83_RS14510 2949474..2950007 - 534 WP_003899412.1 HK97 family phage prohead protease -
DDF83_RS14515 2950160..2950651 - 492 WP_003900541.1 phage terminase small subunit P27 family -
DDF83_RS14520 2950818..2951141 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
DDF83_RS14525 2951221..2951466 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
DDF83_RS14530 2951463..2952890 - 1428 WP_050954864.1 DUF3631 domain-containing protein -
DDF83_RS14535 2952892..2953284 - 393 WP_003899417.1 DUF2742 domain-containing protein -
DDF83_RS14540 2953281..2953541 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
DDF83_RS14545 2953558..2953920 - 363 WP_003900543.1 hypothetical protein -
DDF83_RS14550 2953923..2955050 - 1128 WP_003899420.1 site-specific integrase -
DDF83_RS14555 2955195..2955422 - 228 WP_003899421.1 hypothetical protein -
DDF83_RS14560 2955419..2955808 - 390 WP_003899422.1 hypothetical protein -
DDF83_RS14565 2955714..2955986 + 273 WP_003900544.1 hypothetical protein -
DDF83_RS14570 2956085..2956318 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2946141..2955050 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T104725 WP_003903987.1 NZ_CP029065:c2951141-2950818 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T104725 NZ_CP029065:c2951141-2950818 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT104725 WP_003899415.1 NZ_CP029065:c2951466-2951221 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT104725 NZ_CP029065:c2951466-2951221 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References