Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3723659..3724315 Replicon chromosome
Accession NZ_CP028949
Organism Serratia marcescens strain AR_0121

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AM368_RS17680 Protein ID WP_033648839.1
Coordinates 3723926..3724315 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AM368_RS17675 Protein ID WP_033648840.1
Coordinates 3723659..3723922 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM368_RS17655 3718740..3719789 - 1050 WP_033635553.1 class I fructose-bisphosphate aldolase -
AM368_RS17660 3720079..3720984 - 906 WP_033635546.1 lipid kinase YegS -
AM368_RS17665 3721448..3722800 - 1353 WP_033654556.1 tRNA 5-hydroxyuridine modification protein YegQ -
AM368_RS17670 3722981..3723319 - 339 WP_033648841.1 YegP family protein -
AM368_RS17675 3723659..3723922 + 264 WP_033648840.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AM368_RS17680 3723926..3724315 + 390 WP_033648839.1 type II toxin-antitoxin system VapC family toxin Toxin
AM368_RS17685 3724323..3725039 - 717 WP_033635542.1 two-component system response regulator BaeR -
AM368_RS17690 3725039..3726421 - 1383 WP_033635541.1 two-component system sensor histidine kinase BaeS -
AM368_RS17695 3726418..3727848 - 1431 WP_043147820.1 multidrug transporter subunit MdtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14277.50 Da        Isoelectric Point: 7.8786

>T104470 WP_033648839.1 NZ_CP028949:3723926-3724315 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSVVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T104470 NZ_CP028949:3723926-3724315 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCGTGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10032.29 Da        Isoelectric Point: 4.6702

>AT104470 WP_033648840.1 NZ_CP028949:3723659-3723922 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDADRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT104470 NZ_CP028949:3723659-3723922 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATGCGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCACAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References