Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 3055890..3056485 Replicon chromosome
Accession NZ_CP028949
Organism Serratia marcescens strain AR_0121

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AM368_RS14550 Protein ID WP_072071906.1
Coordinates 3055890..3056144 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM368_RS14555 Protein ID WP_033633573.1
Coordinates 3056144..3056485 (+) Length 114 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM368_RS14535 3052257..3052469 + 213 WP_072071909.1 hypothetical protein -
AM368_RS14540 3052630..3054426 + 1797 WP_072071908.1 type I restriction-modification system subunit M -
AM368_RS14545 3054423..3055505 + 1083 WP_072071907.1 restriction endonuclease -
AM368_RS14550 3055890..3056144 + 255 WP_072071906.1 type II toxin-antitoxin system HicA family toxin Toxin
AM368_RS14555 3056144..3056485 + 342 WP_033633573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM368_RS14560 3056530..3057564 - 1035 WP_048321966.1 phage portal protein -
AM368_RS14565 3057564..3059336 - 1773 WP_033632041.1 terminase ATPase subunit family protein -
AM368_RS14570 3059479..3060294 + 816 WP_048321965.1 GPO family capsid scaffolding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-Ic rfaE 3043766..3102630 58864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(23-81)

Antitoxin

(55-100)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 9526.00 Da        Isoelectric Point: 11.1073

>T104467 WP_072071906.1 NZ_CP028949:3055890-3056144 [Serratia marcescens]
MNKRHQKTLSDVFTRPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

>T104467 NZ_CP028949:3055890-3056144 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTACCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12399.90 Da        Isoelectric Point: 4.5789

>AT104467 WP_033633573.1 NZ_CP028949:3056144-3056485 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 342 bp

>AT104467 NZ_CP028949:3056144-3056485 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCTATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References