Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 740910..741547 Replicon chromosome
Accession NZ_CP028941
Organism Polynucleobacter sp. LimPoW16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DCO16_RS03815 Protein ID WP_173942426.1
Coordinates 740910..741233 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCO16_RS03820 Protein ID WP_173942427.1
Coordinates 741230..741547 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCO16_RS03775 736472..737287 + 816 WP_173942420.1 FAD:protein FMN transferase -
DCO16_RS03780 737306..737749 + 444 WP_173942421.1 hypothetical protein -
DCO16_RS03785 737798..737983 - 186 WP_173943761.1 DUF2892 domain-containing protein -
DCO16_RS03790 738022..738339 - 318 WP_173942422.1 metalloregulator ArsR/SmtB family transcription factor -
DCO16_RS03795 738373..739230 - 858 WP_173943762.1 MBL fold metallo-hydrolase -
DCO16_RS03800 739347..740186 + 840 WP_173942423.1 sulfite exporter TauE/SafE family protein -
DCO16_RS03805 740215..740478 - 264 WP_173942424.1 Txe/YoeB family addiction module toxin -
DCO16_RS03810 740475..740717 - 243 WP_173942425.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DCO16_RS03815 740910..741233 + 324 WP_173942426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCO16_RS03820 741230..741547 + 318 WP_173942427.1 helix-turn-helix domain-containing protein Antitoxin
DCO16_RS03825 741627..742118 + 492 WP_173942428.1 hypothetical protein -
DCO16_RS03830 742132..743007 - 876 Protein_742 EamA family transporter -
DCO16_RS03835 743051..744685 - 1635 WP_173942429.1 GMC family oxidoreductase N-terminal domain-containing protein -
DCO16_RS03840 744803..745102 + 300 WP_173942430.1 type II toxin-antitoxin system RelE/ParE family toxin -
DCO16_RS03845 745119..745430 + 312 WP_173942431.1 helix-turn-helix domain-containing protein -
DCO16_RS03850 745473..746000 + 528 WP_173942432.1 DUF615 domain-containing protein -
DCO16_RS03855 746017..746205 - 189 WP_173942433.1 hypothetical protein -
DCO16_RS03860 746230..746400 - 171 WP_173942434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-99)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12290.49 Da        Isoelectric Point: 9.6926

>T104407 WP_173942426.1 NZ_CP028941:740910-741233 [Polynucleobacter sp. LimPoW16]
MVYSILYYSQEVQEDIMSLPATLQARYIGLTNRMMEYGPNLGLPHTDSFGGGLFELRLKGAEGIARVFFCTMVGQEIIML
HSFIKKTQKTPDKELKLAKQRMKELRK

Download         Length: 324 bp

>T104407 NZ_CP028941:740910-741233 [Polynucleobacter sp. LimPoW16]
ATGGTCTATTCAATCCTTTATTACAGCCAAGAAGTTCAAGAAGACATCATGAGTTTGCCTGCAACACTACAAGCCCGTTA
TATTGGCTTAACTAATCGAATGATGGAGTATGGTCCTAATTTAGGCTTGCCGCATACTGATTCTTTTGGCGGTGGTCTAT
TTGAATTAAGGCTTAAGGGTGCCGAGGGTATTGCGAGGGTTTTCTTTTGCACAATGGTTGGACAAGAAATTATCATGCTC
CATAGTTTTATCAAGAAGACGCAAAAGACCCCAGATAAAGAATTAAAACTTGCCAAGCAACGCATGAAGGAGTTGAGGAA
ATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11452.50 Da        Isoelectric Point: 10.9945

>AT104407 WP_173942427.1 NZ_CP028941:741230-741547 [Polynucleobacter sp. LimPoW16]
MTIKINKSSKTLTHKQMVGKMLKNSAVKAEVDKLNREEFAILDEILTARKEAGLSQAQIAKRMGTQAPAIARLESALATG
KHSPSLSTLRKYAAALGKRVELHLV

Download         Length: 318 bp

>AT104407 NZ_CP028941:741230-741547 [Polynucleobacter sp. LimPoW16]
ATGACGATAAAAATCAATAAAAGCAGCAAAACTCTGACACACAAACAAATGGTCGGCAAGATGCTTAAGAATTCGGCCGT
TAAAGCCGAGGTGGATAAACTCAATCGTGAGGAGTTTGCAATTTTGGATGAGATTCTTACCGCCAGAAAAGAAGCGGGGC
TATCTCAAGCCCAAATTGCTAAACGTATGGGAACACAAGCGCCTGCCATTGCTAGATTAGAAAGTGCCTTAGCCACCGGA
AAACATTCCCCAAGTCTAAGTACCCTCAGAAAGTATGCAGCGGCCCTAGGCAAGAGAGTGGAACTGCACTTAGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References