Detailed information of TA system TA104405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 340408..340991
• Replicon: chromosome
• Accession: NZ_CP028941
• Organism: Polynucleobacter sp. LimPoW16

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DCO16_RS01915
• Protein ID: WP_173942096.1
• Coordinates: 340408..340749 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DCO16_RS01920
• Protein ID: WP_173942097.1
• Coordinates: 340749..340991 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCO16_RS01880	336190..337044	+	855	WP_173942089.1	carboxylating nicotinate-nucleotide diphosphorylase	-
DCO16_RS01885	337057..337395	-	339	WP_173942090.1	transcriptional regulator	-
DCO16_RS01890	337388..337765	-	378	WP_173942091.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DCO16_RS01895	337950..338240	+	291	WP_173942092.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DCO16_RS01900	338246..338551	+	306	WP_173942093.1	putative addiction module antidote protein	-
DCO16_RS01905	338553..338747	+	195	WP_173942094.1	hypothetical protein	-
DCO16_RS01910	338744..340405	-	1662	WP_173942095.1	L-aspartate oxidase	-
DCO16_RS01915	340408..340749	-	342	WP_173942096.1	endoribonuclease MazF	Toxin
DCO16_RS01920	340749..340991	-	243	WP_173942097.1	PbsX family transcriptional regulator	Antitoxin
DCO16_RS01925	341110..343995	-	2886	WP_173942098.1	formate dehydrogenase subunit alpha	-
DCO16_RS01930	344013..345827	-	1815	WP_173942099.1	NAD(P)H-dependent oxidoreductase subunit E	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (9-109)

Antitoxin

• Antitoxin PemI-like (1-79)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12665.90 Da
• Isoelectric Point: 9.5049

>T104405 WP_173942096.1 NZ_CP028941:c340749-340408 [Polynucleobacter sp. LimPoW16]
MVKAYVPDAGDIVWLEFNPQAGHEQAGRRPALVITPELYNKKTNLMICCPLTTQIKGYPFEVLIEMDGIDSAILSDQLKS
LDWKVRKAKFKNKVSAFTLSEVRSKAKALLLIS

Nucleotide

• Length: 342 bp

>T104405 NZ_CP028941:c340749-340408 [Polynucleobacter sp. LimPoW16]
ATGGTGAAGGCTTATGTCCCTGATGCAGGAGACATCGTTTGGCTGGAATTCAATCCGCAAGCTGGTCACGAACAAGCTGG
TCGTCGCCCTGCCTTGGTGATAACTCCTGAGCTTTACAATAAAAAAACCAATCTTATGATTTGCTGCCCGCTCACCACAC
AAATTAAAGGGTATCCTTTTGAAGTGTTAATAGAGATGGACGGTATTGACTCCGCAATTCTTTCTGATCAATTGAAGTCC
TTAGATTGGAAGGTGAGAAAGGCAAAGTTCAAAAACAAAGTGAGTGCATTCACGCTATCAGAAGTGAGAAGCAAGGCAAA
AGCTTTGTTATTAATCTCCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.53 Da
• Isoelectric Point: 10.1505

>AT104405 WP_173942097.1 NZ_CP028941:c340991-340749 [Polynucleobacter sp. LimPoW16]
MQTIIKKWGNSPALRLNTAVMKSAHLNIDQLVSVKVQKGRIVIEPITQLEYQLHDLLAGMTPKNSHHEIDFGKSVGKELL

Nucleotide

• Length: 243 bp

>AT104405 NZ_CP028941:c340991-340749 [Polynucleobacter sp. LimPoW16]
ATGCAAACAATCATTAAAAAATGGGGTAACAGCCCAGCCTTACGGTTGAATACGGCCGTCATGAAGTCTGCCCATCTCAA
TATTGATCAACTCGTCTCTGTAAAAGTCCAAAAAGGCCGTATTGTTATTGAGCCAATCACGCAGTTAGAGTATCAGCTTC
ATGATCTACTCGCGGGAATGACGCCAAAAAACAGTCATCATGAGATTGACTTTGGTAAATCGGTCGGAAAAGAGTTGCTT
TAA