Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 337950..338551 Replicon chromosome
Accession NZ_CP028941
Organism Polynucleobacter sp. LimPoW16

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DCO16_RS01895 Protein ID WP_173942092.1
Coordinates 337950..338240 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag DCO16_RS01900 Protein ID WP_173942093.1
Coordinates 338246..338551 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCO16_RS01860 333049..333339 - 291 WP_173942085.1 nucleotidyltransferase family protein -
DCO16_RS01865 333582..334139 - 558 WP_173942086.1 hypothetical protein -
DCO16_RS01870 334247..334819 - 573 WP_173942087.1 phasin family protein -
DCO16_RS01875 335063..336190 + 1128 WP_173942088.1 quinolinate synthase NadA -
DCO16_RS01880 336190..337044 + 855 WP_173942089.1 carboxylating nicotinate-nucleotide diphosphorylase -
DCO16_RS01885 337057..337395 - 339 WP_173942090.1 transcriptional regulator -
DCO16_RS01890 337388..337765 - 378 WP_173942091.1 type II toxin-antitoxin system RelE/ParE family toxin -
DCO16_RS01895 337950..338240 + 291 WP_173942092.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCO16_RS01900 338246..338551 + 306 WP_173942093.1 putative addiction module antidote protein Antitoxin
DCO16_RS01905 338553..338747 + 195 WP_173942094.1 hypothetical protein -
DCO16_RS01910 338744..340405 - 1662 WP_173942095.1 L-aspartate oxidase -
DCO16_RS01915 340408..340749 - 342 WP_173942096.1 endoribonuclease MazF -
DCO16_RS01920 340749..340991 - 243 WP_173942097.1 PbsX family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-84)

Antitoxin

Uncharacterized protein HI1420

(3-98)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10838.62 Da        Isoelectric Point: 10.4299

>T104404 WP_173942092.1 NZ_CP028941:337950-338240 [Polynucleobacter sp. LimPoW16]
MIEIRKTADFSAWLDSLFDLTARAKIQARIKRISEGNAGDSKSVGEKVFEMKIDFGPGYRVYFTKQGKIIIILLIGGDKD
SQNKDIKFAQRLAKNL

Download         Length: 291 bp

>T104404 NZ_CP028941:337950-338240 [Polynucleobacter sp. LimPoW16]
ATGATAGAAATCAGGAAAACAGCTGACTTTAGTGCCTGGCTTGACAGCCTTTTCGACTTAACAGCAAGAGCAAAAATTCA
GGCAAGAATAAAAAGAATAAGTGAAGGAAATGCAGGTGACAGCAAGTCGGTTGGAGAAAAAGTCTTTGAAATGAAAATTG
ATTTTGGGCCAGGCTACCGTGTTTACTTCACGAAGCAGGGGAAAATAATCATCATTCTTTTAATTGGTGGCGATAAAGAC
TCGCAAAATAAGGATATTAAGTTTGCTCAACGTTTAGCAAAAAACTTATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10966.58 Da        Isoelectric Point: 7.3557

>AT104404 WP_173942093.1 NZ_CP028941:338246-338551 [Polynucleobacter sp. LimPoW16]
MKKTITTPYDVADHLRTPQEMAAYLEACIEESNGDPAFITKALGDIARAKGMTQVAKDAGLSRESLYKALSGDHSPGFDT
ILRVMHALGLSFHAVPSYKKV

Download         Length: 306 bp

>AT104404 NZ_CP028941:338246-338551 [Polynucleobacter sp. LimPoW16]
ATGAAAAAAACAATCACTACCCCATATGATGTTGCGGATCATCTTCGTACTCCGCAAGAAATGGCTGCGTATTTAGAGGC
ATGTATTGAAGAATCCAATGGAGATCCAGCATTTATTACAAAAGCACTTGGTGATATTGCTAGAGCCAAGGGCATGACTC
AGGTTGCAAAAGATGCAGGGCTTTCAAGAGAAAGTTTATACAAAGCCCTCTCGGGTGACCACAGCCCAGGTTTTGACACC
ATTCTTCGCGTGATGCATGCTCTCGGGCTCAGTTTTCATGCTGTACCAAGTTATAAAAAAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References