Detailed information of TA system TA104238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3575317..3575839
• Replicon: chromosome
• Accession: NZ_CP028813
• Organism: Edwardsiella ictaluri strain MS-17-156

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: DBV23_RS17075
• Protein ID: WP_015871319.1
• Coordinates: 3575317..3575598 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: DBV23_RS17080
• Protein ID: WP_015871318.1
• Coordinates: 3575588..3575839 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBV23_RS17060	3570704..3571480	+	777	WP_015871322.1	hypothetical protein	-
DBV23_RS17065	3571473..3573134	+	1662	WP_050977403.1	terminase	-
DBV23_RS17070	3573131..3575245	+	2115	WP_015871320.1	hypothetical protein	-
DBV23_RS17075	3575317..3575598	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBV23_RS17080	3575588..3575839	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DBV23_RS17085	3576127..3577128	+	1002	WP_107775275.1	hypothetical protein	-
DBV23_RS17090	3577146..3578402	+	1257	WP_015871316.1	N4-gp56 family major capsid protein	-
DBV23_RS17095	3578560..3578955	+	396	WP_015871315.1	hypothetical protein	-
DBV23_RS17100	3578997..3579440	+	444	WP_015871314.1	hypothetical protein	-
DBV23_RS17105	3579440..3580021	+	582	WP_015871313.1	hypothetical protein	-
DBV23_RS17110	3580021..3580683	+	663	WP_015871312.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3520125..3610184	90059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T104238 WP_015871319.1 NZ_CP028813:c3575598-3575317 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T104238 NZ_CP028813:c3575598-3575317 [Edwardsiella ictaluri]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT104238 WP_015871318.1 NZ_CP028813:c3575839-3575588 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT104238 NZ_CP028813:c3575839-3575588 [Edwardsiella ictaluri]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3