Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 830105..830940 Replicon chromosome
Accession NZ_CP028772
Organism Escherichia coli strain A2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag AOY53_RS04020 Protein ID WP_000854821.1
Coordinates 830105..830482 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag AOY53_RS04025 Protein ID WP_001285610.1
Coordinates 830572..830940 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY53_RS03985 (825186) 825186..825785 + 600 WP_039022610.1 type II secretion system minor pseudopilin GspJ -
AOY53_RS03990 (825788) 825788..826765 + 978 WP_000633238.1 type II secretion system minor pseudopilin GspK -
AOY53_RS03995 (826762) 826762..827940 + 1179 WP_032283517.1 type II secretion system protein GspL -
AOY53_RS04000 (827942) 827942..828478 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
AOY53_RS04005 (828759) 828759..829601 - 843 WP_089552761.1 DUF4942 domain-containing protein -
AOY53_RS04010 (829686) 829686..829883 - 198 WP_085949090.1 DUF957 domain-containing protein -
AOY53_RS04015 (829911) 829911..830108 - 198 Protein_788 DUF5983 family protein -
AOY53_RS04020 (830105) 830105..830482 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
AOY53_RS04025 (830572) 830572..830940 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY53_RS04030 (831020) 831020..831241 - 222 WP_000692350.1 DUF987 domain-containing protein -
AOY53_RS04035 (831328) 831328..831804 - 477 WP_040089737.1 RadC family protein -
AOY53_RS04040 (831820) 831820..832305 - 486 WP_061157977.1 antirestriction protein -
AOY53_RS04045 (832397) 832397..833215 - 819 WP_001610805.1 DUF932 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / faeC / faeD / faeE / faeF / faeH / faeI / faeJ 725914..877105 151191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T104085 WP_000854821.1 NZ_CP028772:c830482-830105 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T104085 NZ_CP028772:c830482-830105 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT104085 WP_001285610.1 NZ_CP028772:c830940-830572 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT104085 NZ_CP028772:c830940-830572 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54


Antitoxin

Source ID Structure

References